| Gene Symbol |
PJA1
|
| Entrez Gene |
64219
|
| Alt Symbol |
PRAJA1, RNF70
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
praja ring finger 1, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase Praja-1|RING finger protein 70|praja 1
|
| Swissprots |
Q9HAC1 Q5JUT9 Q5JUT8 A2A322 Q8NG27 Q8NG28
|
| Accessions |
EAX05367 EAX05368 EAX05369 Q8NG27 AF262024 AAM53039 AF264620 AAM53040 AK021892 BAB13928 AK096611 BAG53338 AK226171 AK290543 BAF83232 AK293266 BAG56796 AK294632 BAG57811 BC039149 BC048323 AAH48323 BC058327 BC075803 AAH75803 BC105051 AAI05052 BC105053 AAI05054 BC113035 AAI13036 BM127146 DA778001 DC349747 EU446995 ABZ92524 XM_005262292 XP_005262349 XM_011531011 XP_011529313 NM_001032396 NP_001027568 NM_022368 NP_071763 NM_145119 NP_660095
|
| Function |
Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. {ECO:0000250, ECO:0000269|PubMed:12036302}.
|
| Tissue Specificity |
Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex. {ECO:0000269|PubMed:12036302}.
|
![Western Blot: RNF70 Overexpression Lysate (Adult Normal) [NBL1-14453] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RNF70.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3805_RNF70%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14453-img0002.jpg)