Gene Symbol | PJA1 |
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Entrez Gene | 64219 |
Alt Symbol | PRAJA1, RNF70 |
Species | Human |
Gene Type | protein-coding |
Description | praja ring finger 1, E3 ubiquitin protein ligase |
Other Description | E3 ubiquitin-protein ligase Praja-1|RING finger protein 70|praja 1 |
Swissprots | Q9HAC1 Q5JUT9 Q5JUT8 A2A322 Q8NG27 Q8NG28 |
Accessions | EAX05367 EAX05368 EAX05369 Q8NG27 AF262024 AAM53039 AF264620 AAM53040 AK021892 BAB13928 AK096611 BAG53338 AK226171 AK290543 BAF83232 AK293266 BAG56796 AK294632 BAG57811 BC039149 BC048323 AAH48323 BC058327 BC075803 AAH75803 BC105051 AAI05052 BC105053 AAI05054 BC113035 AAI13036 BM127146 DA778001 DC349747 EU446995 ABZ92524 XM_005262292 XP_005262349 XM_011531011 XP_011529313 NM_001032396 NP_001027568 NM_022368 NP_071763 NM_145119 NP_660095 |
Function | Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting. {ECO:0000250, ECO:0000269|PubMed:12036302}. |
Tissue Specificity | Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex. {ECO:0000269|PubMed:12036302}. |
PJA1 CRISPR/Cas9 KO Plasmid (h) - sc-412995 from Santa Cruz Biotechnology
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PJA1 HDR Plasmid (h) - sc-412995-HDR from Santa Cruz Biotechnology
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PJA1 Double Nickase Plasmid (h) - sc-412995-NIC from Santa Cruz Biotechnology
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PJA1 Double Nickase Plasmid (h2) - sc-412995-NIC-2 from Santa Cruz Biotechnology
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PJA1 CRISPR Activation Plasmid (h) - sc-412995-ACT from Santa Cruz Biotechnology
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PJA1 CRISPR Activation Plasmid (h2) - sc-412995-ACT-2 from Santa Cruz Biotechnology
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PJA1 Lentiviral Activation Particles (h) - sc-412995-LAC from Santa Cruz Biotechnology
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PJA1 Lentiviral Activation Particles (h2) - sc-412995-LAC-2 from Santa Cruz Biotechnology
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PJA1 siRNA (h) - sc-91297 from Santa Cruz Biotechnology
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PJA1 shRNA Plasmid (h) - sc-91297-SH from Santa Cruz Biotechnology
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PJA1 shRNA (h) Lentiviral Particles - sc-91297-V from Santa Cruz Biotechnology
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RNF70 RNAi - H00064219-R02 from Novus Biologicals
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MISSION® esiRNA - EHU062891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16851 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04153 from Sigma-Aldrich
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PJA1 siRNA (Human) - CRJ1963 from Cohesion Biosciences
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RNF70 RNAi - H00064219-R01 from Novus Biologicals
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shRNA set against Human PJA1 (NM_145119.3) - SHH376324 from Creative biogene
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Human PJA1 siRNA - orb272464 from Biorbyt
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PJA1 shRNA Plasmid (Human) - CHJ1963 from Cohesion Biosciences
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PJA1 miRNA 3'UTR clone - MiUTR3H-02770 from Creative biogene
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PJA1 miRNA 3'UTR clone - MiUTR3H-02771 from Creative biogene
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PJA1 miRNA 3'UTR clone - MiUTR3H-02772 from Creative biogene
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