| Gene Symbol |
DNMT3B
|
| Entrez Gene |
1789
|
| Alt Symbol |
ICF, ICF1, M.HsaIIIB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DNA (cytosine-5-)-methyltransferase 3 beta
|
| Other Description |
DNA (cytosine-5)-methyltransferase 3B|DNA MTase HsaIIIB|DNA methyltransferase HsaIIIB
|
| Swissprots |
Q9UKA6 Q9UJQ5 A2A2E2 B4DSM8 E1P5M7 Q9UBD4 Q9Y5S0 Q9UBC3 B4DSU1 Q9Y5R9 E7EN63 E9PBF2 Q9UNE5 E1P5M6
|
| Accessions |
EAW76350 EAW76351 EAW76352 EAW76353 EAW76354 EAW76355 EAW76356 Q9UBC3 AB208880 BAD92117 AF129267 AAD31432 AF129268 AAD31433 AF129269 AAD31434 AF156487 AAD53062 AF156488 AAD53063 AF176228 AAF04015 AF331857 AAL57040 AK001191 BAG50865 AK295176 BAG58185 AK299776 BAG61659 AK299821 BAG61690 AK299915 BAG61753 AK300857 BAG62507 BC111933 AAI11934 BC118502 AAI18503 DQ321787 ABC48951 L32168 XM_011528653 XP_011526955 XM_011528654 XP_011526956 XR_936510 XR_936511 XR_936512 NM_001207055 NP_001193984 NM_001207056 NP_001193985 NM_006892 NP_008823 NM_175848 NP_787044 NM_175849 NP_787045 NM_175850 NP_787046
|
| Function |
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. {ECO:0000250, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:17303076, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18567530}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11735126, ECO:0000269|PubMed:12145218}.
|
| Tissue Specificity |
Ubiquitous; highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate.
|
| Top Pathways |
Cysteine and methionine metabolism, MicroRNAs in cancer
|