DNMT3B

Gene Symbol	DNMT3B
Entrez Gene	1789
Alt Symbol	ICF, ICF1, M.HsaIIIB
Species	Human
Gene Type	protein-coding
Description	DNA (cytosine-5-)-methyltransferase 3 beta
Other Description	DNA (cytosine-5)-methyltransferase 3B|DNA MTase HsaIIIB|DNA methyltransferase HsaIIIB
Swissprots	Q9UKA6 Q9UJQ5 A2A2E2 B4DSM8 E1P5M7 Q9UBD4 Q9Y5S0 Q9UBC3 B4DSU1 Q9Y5R9 E7EN63 E9PBF2 Q9UNE5 E1P5M6
Accessions	EAW76350 EAW76351 EAW76352 EAW76353 EAW76354 EAW76355 EAW76356 Q9UBC3 AB208880 BAD92117 AF129267 AAD31432 AF129268 AAD31433 AF129269 AAD31434 AF156487 AAD53062 AF156488 AAD53063 AF176228 AAF04015 AF331857 AAL57040 AK001191 BAG50865 AK295176 BAG58185 AK299776 BAG61659 AK299821 BAG61690 AK299915 BAG61753 AK300857 BAG62507 BC111933 AAI11934 BC118502 AAI18503 DQ321787 ABC48951 L32168 XM_011528653 XP_011526955 XM_011528654 XP_011526956 XR_936510 XR_936511 XR_936512 NM_001207055 NP_001193984 NM_001207056 NP_001193985 NM_006892 NP_008823 NM_175848 NP_787044 NM_175849 NP_787045 NM_175850 NP_787046
Function	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co- repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1. {ECO:0000250, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:17303076, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18567530}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:11735126, ECO:0000269|PubMed:12145218}.
Tissue Specificity	Ubiquitous; highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate.
Top Pathways	Cysteine and methionine metabolism, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Dnmt3b full length protein - ab170410 from Abcam Category Protein Prices $352.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Dnmt3b peptide - ab4922 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

Human Dnmt3b protein fragment - ab114187 from Abcam Category Protein Source Wheat germ Species Human

Mouse Dnmt3b full length protein - ab198091 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Mouse

Mouse Dnmt3b peptide - ab16376 from Abcam Category Peptide

DNMT3B Antibody Blocking Peptide - LS-E176 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNMT3B Antibody Blocking Peptide - LS-E17770 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DNMT3B Protein - NBP2-26582 from Novus Biologicals Category Protein Prices $149.00 Sizes 100 µl Species Human

Recombinant Human DNMT3B Protein - H00001789-Q01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Dnmt3b-Antibody-Blocking-Peptide - BP1035a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DNMT3B Blocking Peptide - 33R-3607 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DNMT3B Blocking Peptide - abx062543 from Abbexa Category Peptide Species Human, Monkey

DNMT3B - H00001789-Q01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

DNMT3B - H00001789-Q01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Source in vitro transl. Species Human

DNMT3B - H00001789-Q01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Source in vitro transl. Species Human

Dnmt3b Peptide - 350465 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human DNMT3B - DNMT3B-26884TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human DNMT3B, GST-tagged - DNMT3B-165H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human DNMT3B, GST-tagged - DNMT3B-258H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant DNA Methyltransferase 3B (DNMT3B) - RPJ246Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant DNA Methyltransferase 3B (DNMT3B) - RPJ246Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant DNA Methyltransferase 3B (DNMT3B) - RPJ246Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

DNMT3B Blocking Peptide - CBP1349 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

DNMT3B (H7) Peptide - BS2572P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant DNA Methyltransferase 3B (DNMT3B) - RPJ246Hu01 from Cloud-clone Category Protein Source E.coli Species Human

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