| Gene Symbol |
RFWD3
|
| Entrez Gene |
55159
|
| Alt Symbol |
RNF201
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger and WD repeat domain 3
|
| Other Description |
E3 ubiquitin-protein ligase RFWD3|RING finger and WD repeat domain-containing protein 3|RING finger protein 201
|
| Swissprots |
Q5XKR3 D3DUJ8 A8K585 Q9H9Q3 Q9NVT4 B2RE35 Q6PCD5
|
| Accessions |
EAW95680 EAW95681 Q6PCD5 AK001382 BAA91662 AK022673 BAB14169 AK291200 BAF83889 AK296727 BAG59315 AK315786 BAG38132 BC002574 AAH02574 BC059371 AAH59371 BM467919 BP872110 XM_005256021 XP_005256078 XM_005256022 XP_005256079 XM_006721228 XP_006721291 XM_011523191 XP_011521493 NM_018124 NP_060594
|
| Function |
E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair. {ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:21558276}.
|
| Subcellular Location |
Nucleus. Nucleus, PML body. Cytoplasm. Note=In undamaged cells, found both in the cytoplasm and in the nucleus, partially associated with PML nuclear bodies. In response to replication block, such as that caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the nucleus, to stalled replication forks or to sites of DNA repair. This recruitment depends upon RPA2.
|