RFWD3

Gene Symbol	RFWD3
Entrez Gene	55159
Alt Symbol	RNF201
Species	Human
Gene Type	protein-coding
Description	ring finger and WD repeat domain 3
Other Description	E3 ubiquitin-protein ligase RFWD3|RING finger and WD repeat domain-containing protein 3|RING finger protein 201
Swissprots	Q5XKR3 D3DUJ8 A8K585 Q9H9Q3 Q9NVT4 B2RE35 Q6PCD5
Accessions	EAW95680 EAW95681 Q6PCD5 AK001382 BAA91662 AK022673 BAB14169 AK291200 BAF83889 AK296727 BAG59315 AK315786 BAG38132 BC002574 AAH02574 BC059371 AAH59371 BM467919 BP872110 XM_005256021 XP_005256078 XM_005256022 XP_005256079 XM_006721228 XP_006721291 XM_011523191 XP_011521493 NM_018124 NP_060594
Function	E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair. {ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:21504906, ECO:0000269|PubMed:21558276}.
Subcellular Location	Nucleus. Nucleus, PML body. Cytoplasm. Note=In undamaged cells, found both in the cytoplasm and in the nucleus, partially associated with PML nuclear bodies. In response to replication block, such as that caused by hydroxyurea treatment, or to DNA damage caused by ionizing radiations or doxorubicin, recruited to the nucleus, to stalled replication forks or to sites of DNA repair. This recruitment depends upon RPA2.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RFWD3 protein fragment - ab162990 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human RFWD3 Protein - H00055159-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RFWD3 / RNF201 - H00055159-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RFWD3 / RNF201 - H00055159-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RFWD3 fusion protein - ag13728 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

RFWD3 fusion protein - Ag13769 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human E3 ubiquitin-protein ligase RFWD3(RFWD3) - CSB-YP744106HU CSB-EP744106HU CSB-BP744106HU CSB-MP744106HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RFWD3 Blocking Peptide - CBP4202 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

RFWD3 Blocking Peptide - abx161413 from Abbexa Category Peptide Species Human

RFWD3 Peptide, Human - M34GP13203H from Creative Peptides Category Peptide Source Synthetic. Species Human

RFWD3 Recombinant Protein Antigen - NBP2-58819PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RFWD3 Recombinant Protein Antigen - NBP2-57566PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

E3 ubiquitin-protein ligase RFWD3 (RFWD3), Recombinant Protein - MBS1386058 from MyBioSource Category Protein Prices $1,590.00, $1,590.00, $1,820.00, $1,820.00, $2,750.00, $2,750.00, $3,190.00, $3,190.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RFWD3 peptide - orb304793 from Biorbyt Category Peptide

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