ADAM15

Gene Symbol ADAM15
Entrez Gene 8751
Alt Symbol MDC15
Species Human
Gene Type protein-coding
Description ADAM metallopeptidase domain 15
Other Description MDC-15|a disintegrin and metalloproteinase domain 15 (metargidin)|disintegrin and metalloproteinase domain-containing protein 15|metalloprotease RGD disintegrin protein|metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
Swissprots Q13493 Q53XQ0 Q71S68 Q71S65 Q71S62 Q13444 B3KQU5 B4DLB5 U3KQL5 Q71S67 Q5SR68 Q71S66 Q96C78 Q5SR69 Q71S69 E9PN65 Q71S63 Q71S64 Q6R267 B4DMH8 Q71S61
Accessions AAM44189 AAS48590 AAS48591 AAS48592 AAS48593 AAS48594 AAS48595 AAS48596 AAS48597 AAS72298 Q13444 AB209157 BAD92394 AK000667 AK075498 BAG52157 AK295614 BAH12126 AK296925 BAG59477 AK297468 BAG59890 AK308172 AW290953 AY518542 AAR99331 AY560593 AAS72991 AY560594 AAS72992 AY560595 AAS72993 AY560596 AAS72994 AY560597 AAS72995 AY560598 AAS72996 AY560599 AAS72997 AY560600 AAS72998 AY560601 AAS72999 AY576417 AAS73000 BC014566 AAH14566 BM971880 BT009764 AAP88766 EU176173 ABW03624 U41767 AAC50404 U46005 AAC51112 NM_001261464 NP_001248393 NM_001261465 NP_001248394 NM_001261466 NP_001248395 NM_003815 NP_003806 NM_207191 NP_997074 NM_207194 NP_997077 NM_207195 NP_997078 NM_207196 NP_997079 NM_207197 NP_997080 NR_048577 NR_048578 NR_048579
Function Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333
Subcellular Location Endomembrane system {ECO:0000269|PubMed:12243749}; Single-pass type I membrane protein {ECO:0000269|PubMed:12243749}. Cell junction, adherens junction {ECO:0000269|PubMed:12243749}. Cell projection, cilium, flagellum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed (By similarity). {ECO:0000250}.
Tissue Specificity Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:9016778}.

ADAM15 (C-20) - sc-16530 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAM15 (C-20): sc-16530. Western blot analysis of ADAM15 expression in Jurkat whole cell lysate.

ADAM15 (E-14) - sc-21684 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAM15 (E-14): sc-21684. Immunofluorescence staining of methanol-fixed Jurkat cells showing membrane localization.

ADAM15 (H-60) - sc-25580 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ADAM15 (D-5) - sc-365752 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ADAM15 (D-5): sc-365752. Western blot analysis of ADAM15 expression in Jurkat (A) and HCT 116 (B) whole cell lysates.

ADAM15 (M-12) - sc-21688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAM15 (M-12): sc-21688. Immunofluorescence staining of methanol-fixed Jurkat cells showing membrane localization.

ADAM15 (V-20) - sc-16529 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ADAM15 (V-20): sc-16529. Western blot analysis of ADAM15 expression in HCT-116 whole cell lysate.

Anti-ADAM15 antibody - ab84834 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ADAM15 antibody (ab84834) at 1/200 dilution + fetal liver lysate

Anti-ADAM15 antibody - ab39160 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab39160 stained Hek293 cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab39160, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-ADAM15 antibody - ab83883 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ADAM15 antibody (ab83883) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal brain lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-ADAM15 antibody - ab172305 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-ADAM15 antibody (ab172305) at 1/500 dilutionLane 1 : Lysate from 293T cells transfected with ADAM15Lane 2 : Lysate from untransfected 293T cellsLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-ADAM15 antibody [EPR5619] - ab124698 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5619
Anti-ADAM15 antibody [EPR5619] (ab124698) at 1/1000 dilution + SW480 cell lysate at 10 µgSecondaryGoat anti-Rabbit HRP at 2000

Anti-ADAM15 antibody [MM0078-9H34] - ab89125 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0078-9H34

Anti-ADAM15 antibody - Catalytic domain - ab28231 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAM15 antibody - Cytoplasmic domain - ab39159 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ADAM15 antibody - Cytoplasmic domain (ab39159) at 1/1000 dilution + cell media from human chondrosarcoma (treated with retinoic acid)

Anti-ADAM15 antibody - N-terminal - ab137387 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ADAM15 antibody - N-terminal (ab137387) at 1/1000 dilution + HepG2 whole cell lysate at 30 µg

Anti-ADAM15 Antibody (C-Terminus) - LS-C3543 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAM15 Antibody (CF) - LS-C124906 from LifeSpan Bioscience

Prices $445.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-ADAM15 Antibody - LS-C124907 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-ADAM15 Antibody (PE) - LS-C124908 from LifeSpan Bioscience

Prices $530.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-ADAM15 Antibody - LS-C285594 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-ADAM15 Antibody (aa211-451, Biotin) - LS-C298067 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAM15 Antibody (APC) - LS-C124909 from LifeSpan Bioscience

Prices $590.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-ADAM15 Antibody (aa211-451, FITC) - LS-C301929 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAM15 Antibody (HRP) - LS-C316914 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ADAM15 Antibody (FITC) - LS-C316916 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Search more