| Gene Symbol |
ADAM15
|
| Entrez Gene |
8751
|
| Alt Symbol |
MDC15
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ADAM metallopeptidase domain 15
|
| Other Description |
MDC-15|a disintegrin and metalloproteinase domain 15 (metargidin)|disintegrin and metalloproteinase domain-containing protein 15|metalloprotease RGD disintegrin protein|metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
|
| Swissprots |
Q13493 Q53XQ0 Q71S68 Q71S65 Q71S62 Q13444 B3KQU5 B4DLB5 U3KQL5 Q71S67 Q5SR68 Q71S66 Q96C78 Q5SR69 Q71S69 E9PN65 Q71S63 Q71S64 Q6R267 B4DMH8 Q71S61
|
| Accessions |
AAM44189 AAS48590 AAS48591 AAS48592 AAS48593 AAS48594 AAS48595 AAS48596 AAS48597 AAS72298 Q13444 AB209157 BAD92394 AK000667 AK075498 BAG52157 AK295614 BAH12126 AK296925 BAG59477 AK297468 BAG59890 AK308172 AW290953 AY518542 AAR99331 AY560593 AAS72991 AY560594 AAS72992 AY560595 AAS72993 AY560596 AAS72994 AY560597 AAS72995 AY560598 AAS72996 AY560599 AAS72997 AY560600 AAS72998 AY560601 AAS72999 AY576417 AAS73000 BC014566 AAH14566 BM971880 BT009764 AAP88766 EU176173 ABW03624 U41767 AAC50404 U46005 AAC51112 NM_001261464 NP_001248393 NM_001261465 NP_001248394 NM_001261466 NP_001248395 NM_003815 NP_003806 NM_207191 NP_997074 NM_207194 NP_997077 NM_207195 NP_997078 NM_207196 NP_997079 NM_207197 NP_997080 NR_048577 NR_048578 NR_048579
|
| Function |
Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333
|
| Subcellular Location |
Endomembrane system {ECO:0000269|PubMed:12243749}; Single-pass type I membrane protein {ECO:0000269|PubMed:12243749}. Cell junction, adherens junction {ECO:0000269|PubMed:12243749}. Cell projection, cilium, flagellum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:9016778}.
|