ADAM15

Gene Symbol	ADAM15
Entrez Gene	8751
Alt Symbol	MDC15
Species	Human
Gene Type	protein-coding
Description	ADAM metallopeptidase domain 15
Other Description	MDC-15|a disintegrin and metalloproteinase domain 15 (metargidin)|disintegrin and metalloproteinase domain-containing protein 15|metalloprotease RGD disintegrin protein|metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
Swissprots	Q13493 Q53XQ0 Q71S68 Q71S65 Q71S62 Q13444 B3KQU5 B4DLB5 U3KQL5 Q71S67 Q5SR68 Q71S66 Q96C78 Q5SR69 Q71S69 E9PN65 Q71S63 Q71S64 Q6R267 B4DMH8 Q71S61
Accessions	AAM44189 AAS48590 AAS48591 AAS48592 AAS48593 AAS48594 AAS48595 AAS48596 AAS48597 AAS72298 Q13444 AB209157 BAD92394 AK000667 AK075498 BAG52157 AK295614 BAH12126 AK296925 BAG59477 AK297468 BAG59890 AK308172 AW290953 AY518542 AAR99331 AY560593 AAS72991 AY560594 AAS72992 AY560595 AAS72993 AY560596 AAS72994 AY560597 AAS72995 AY560598 AAS72996 AY560599 AAS72997 AY560600 AAS72998 AY560601 AAS72999 AY576417 AAS73000 BC014566 AAH14566 BM971880 BT009764 AAP88766 EU176173 ABW03624 U41767 AAC50404 U46005 AAC51112 NM_001261464 NP_001248393 NM_001261465 NP_001248394 NM_001261466 NP_001248395 NM_003815 NP_003806 NM_207191 NP_997074 NM_207194 NP_997077 NM_207195 NP_997078 NM_207196 NP_997079 NM_207197 NP_997080 NR_048577 NR_048578 NR_048579
Function	Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:15818704, ECO:0000269|PubMed:17416588, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:18387333
Subcellular Location	Endomembrane system {ECO:0000269|PubMed:12243749}; Single-pass type I membrane protein {ECO:0000269|PubMed:12243749}. Cell junction, adherens junction {ECO:0000269|PubMed:12243749}. Cell projection, cilium, flagellum {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Note=The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed (By similarity). {ECO:0000250}.
Tissue Specificity	Expressed in colon and small intestine. Expressed in airway smooth muscle and glomerular mesangial cells (at protein level). Ubiquitously expressed. Overexpressed in atherosclerotic lesions. Constitutively expressed in cultured endothelium and smooth muscle. Expressed in chondrocytes. Expressed in airway smooth muscle and glomerular mesangial cells. {ECO:0000269|PubMed:12091380, ECO:0000269|PubMed:15358598, ECO:0000269|PubMed:17575078, ECO:0000269|PubMed:9016778}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ADAM15 peptide - ab41210 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAM15 peptide - ab41211 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ADAM15 peptide - ab41212 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human ADAM15 full length protein - ab131862 from Abcam Category Protein Source Wheat germ Species Human

Human ADAM15 protein fragment - ab160172 from Abcam Category Protein Source Wheat germ Species Human

ADAM15 Antibody Blocking Peptide - LS-E16905 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ADAM15 Protein - H00008751-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ADAM15 Protein - H00008751-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ADAM15 Ecto Domain Western Blot Standard - WBC027 from R&D Systems Category Protein Prices $109.00 Sizes 1 vial Species Human

Human ADAM15 protein - orb246675 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

ADAM15 Blocking Peptide - 33R-7669 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human ADAM15 Protein - abx065058 from Abbexa Category Protein Source E.coli Species Human

ADAM15 / MDC15 - H00008751-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

ADAM15 / MDC15 - H00008751-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ADAM15 / MDC15 - H00008751-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ADAM15 / MDC15 - H00008751-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ADAM15 / MDC15 - H00008751-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

A Disintegrin And Metalloprotease 15 (ADAM15), Human - 20-9399 from ARP American Research Products Category Protein Prices $509.00 Sizes 50 µg Source E.coli Species Human

ADAM15 fusion protein - ag1170 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

ADAM15 fusion protein - ag7996 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human ADAM15, His tagged - ADAM15-243H from Creative Biomart Category Protein Source Human Cells Species Human

Human ADAM15 Recombinant - RKQ13444 from Reprokine Category Protein Prices $160.00, $480.00, $1,950.00 Sizes 5 µg, 20 µg, 100 µg Source Optimized DNA sequence encoding extracellular domain of human Disintegrin and metalloproteinase 15- ADAM15 (ASP207 - THR696) including a C-terminal His tag was expressed in HEK293 cells. Species Human

Recombinant A Disintegrin And Metalloprotease 15 (ADAM15) - RPJ800Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Human ADAM15 / MDC15 Protein (His Tag) - 10517-H08H-10 from Sino Biological Category Protein Source Human Cells Species Human

Human ADAM15 Protein (His Tag) - 10517-H08S-10 from Sino Biological Category Protein Source CHO Stable Cells Species Human

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