Gene Symbol | TMEM123 |
---|---|
Entrez Gene | 114908 |
Alt Symbol | KCT3, PORIMIN, PORMIN |
Species | Human |
Gene Type | protein-coding |
Description | transmembrane protein 123 |
Other Description | KCT-3|keratinocytes associated transmembrane protein 3|keratinocytes-associated transmembrane protein 3|porimin|pro oncosis receptor inducing membrane injury|pro-oncosis receptor inducing membrane injury|serine/threonine-rich receptor |
Swissprots | Q8N131 Q96QV2 Q8IWS2 |
Accessions | CAI72111 EAW67019 EAW67020 EAW67021 Q8N131 AJ293406 AK026572 AK075420 BAC11610 AK225790 AL050161 AL110202 AL137643 AY008283 AAG21694 AY157580 AAO13164 AY358696 AAQ89059 BC032296 AAH32296 DB146474 DQ891654 ABM82580 DQ894842 ABM85768 NM_052932 NP_443164 |
Function | Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. {ECO:0000269|PubMed:11481458}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Ubiquitous. Not expressed in ovary. Expressed in keratinocytes. {ECO:0000269|PubMed:11481458, ECO:0000269|PubMed:12752121}. |