HCK

Gene Symbol	HCK
Entrez Gene	3055
Alt Symbol	JTK9, p59Hck, p61Hck
Species	Human
Gene Type	protein-coding
Description	HCK proto-oncogene, Src family tyrosine kinase
Other Description	hematopoietic cell kinase|hemopoietic cell kinase|p59-HCK/p60-HCK|tyrosine-protein kinase HCK
Swissprots	A8K1I1 Q9NUA4 Q96CC0 Q29RX1 P08631 Q9UMJ5 Q9H5Y5 Q5T7K1 E1P5M2 Q2VPE2 B4DQB6 Q5T7K2 Q504R5
Accessions	CAA41565 EAW76392 EAW76393 EAW76394 P08631 AK026432 BAB15482 AK225819 AK289896 BAF82585 AK290928 BAF83617 AK298726 BAG60878 AK314335 AW139272 BC014435 AAH14435 BC073748 AAH73748 BC094847 AAH94847 BC108930 AAI08931 BC108931 AAI08932 BC113854 AAI13855 BC114463 AAI14464 DA465978 M16592 AAA52644 NM_001172129 NP_001165600 NM_001172130 NP_001165601 NM_001172131 NP_001165602 NM_001172132 NP_001165603 NM_001172133 NP_001165604 NM_002110 NP_002101
Function	Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation
Subcellular Location	Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol.
Tissue Specificity	Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil. {ECO:0000269|PubMed:3453117, ECO:0000269|PubMed:8064233, ECO:0000269|PubMed:8995234}.
Top Pathways	Fc gamma R-mediated phagocytosis, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Phosphotyrosine HCK / Tyrosine-protein Kinase HCK ELISA Kit - RAB0966 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Tyrosine-protein kinase HCK (HCK), Human, ELISA Kit - CSB-EL010211HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

HCK (Human) IP-WB Antibody Pair - H00003055-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HCK (Human) IP-WB Antibody Pair - H00003055-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

HCK (Human) Matched Antibody Pair - H00003055-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

hemopoietic cell kinase, ELISA Kit - MBS916817 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human HCK is typically less than 4.69 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 18.75 pg/ml -1200 pg/ml.

Human Tyrosine-protein kinase HCK(HCK) ELISA kit - CSB-EL010211HU from Cusabio Category ELISA Kit Sensitivity 4.69 pg/ml. Range 18.75 pg/ml-1200 pg/ml

Custom Human Phosphotyrosine HCK ELISA - PEL-HCK-Y-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human HCK ELISA Kit - E018234 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of human HCK is typically less than 4.69 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean

HCK ELISA Kit (Human) (OKCA01577) - OKCA01577 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 4.69 pg/mL Range 18.75 - 1,200 pg/mL

HCK (Tyrosine-protein kinase HCK), ELISA Kit - MBS7606757 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.9pg/ml Range 78-5000pg/ml

Bovine HCK ELISA Kit (Sandwich ELISA) - LS-F31789 from LifeSpan Bioscience Category ELISA Kit Sensitivity 46.9 Range 78-5000 pg/ml

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