HCK

Gene Symbol	HCK
Entrez Gene	3055
Alt Symbol	JTK9, p59Hck, p61Hck
Species	Human
Gene Type	protein-coding
Description	HCK proto-oncogene, Src family tyrosine kinase
Other Description	hematopoietic cell kinase|hemopoietic cell kinase|p59-HCK/p60-HCK|tyrosine-protein kinase HCK
Swissprots	A8K1I1 Q9NUA4 Q96CC0 Q29RX1 P08631 Q9UMJ5 Q9H5Y5 Q5T7K1 E1P5M2 Q2VPE2 B4DQB6 Q5T7K2 Q504R5
Accessions	CAA41565 EAW76392 EAW76393 EAW76394 P08631 AK026432 BAB15482 AK225819 AK289896 BAF82585 AK290928 BAF83617 AK298726 BAG60878 AK314335 AW139272 BC014435 AAH14435 BC073748 AAH73748 BC094847 AAH94847 BC108930 AAI08931 BC108931 AAI08932 BC113854 AAI13855 BC114463 AAI14464 DA465978 M16592 AAA52644 NM_001172129 NP_001165600 NM_001172130 NP_001165601 NM_001172131 NP_001165602 NM_001172132 NP_001165603 NM_001172133 NP_001165604 NM_002110 NP_002101
Function	Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation
Subcellular Location	Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol.
Tissue Specificity	Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil. {ECO:0000269|PubMed:3453117, ECO:0000269|PubMed:8064233, ECO:0000269|PubMed:8995234}.
Top Pathways	Fc gamma R-mediated phagocytosis, Chemokine signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Hck protein fragment - ab60865 from Abcam Category Protein Prices $294.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human Hck full length protein - ab131827 from Abcam Category Protein Source Wheat germ Species Human

Human Hck protein fragment - ab90195 from Abcam Category Protein Source E. coli Species Human

HCK Antibody Blocking Peptide - LS-E3914 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HCK Antibody Blocking Peptide - LS-E22397 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HCK Antibody Blocking Peptide - LS-E9212 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HCK Antibody Blocking Peptide - LS-E9213 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Hck Protein - H00003055-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Hck Protein - H00003055-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Hck Recombinant Protein - P4204 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Hck Recombinant Protein - P3868 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Species Human

Hck Recombinant Protein - P4699 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant Hck Protein - NBP1-99500 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

Hck Peptide - P2753 from Novus Biologicals Category Peptide Species Human

HCK-Antibody-N-term-Blocking-peptide - BP7710d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HCK-Antibody-N-term-Blocking-Peptide - BP7710a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HCK (Active) recombinant protein - GTX65112 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

HCK protein - 30R-2835 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

HCK - H00003055-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HCK - H00003055-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HCK - H00003055-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HCK - H00003055-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HCK - P3868 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

HCK - P4204 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

HCK - P4699 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

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