| Gene Symbol | HCK |
|---|---|
| Entrez Gene | 3055 |
| Alt Symbol | JTK9, p59Hck, p61Hck |
| Species | Human |
| Gene Type | protein-coding |
| Description | HCK proto-oncogene, Src family tyrosine kinase |
| Other Description | hematopoietic cell kinase|hemopoietic cell kinase|p59-HCK/p60-HCK|tyrosine-protein kinase HCK |
| Swissprots | A8K1I1 Q9NUA4 Q96CC0 Q29RX1 P08631 Q9UMJ5 Q9H5Y5 Q5T7K1 E1P5M2 Q2VPE2 B4DQB6 Q5T7K2 Q504R5 |
| Accessions | CAA41565 EAW76392 EAW76393 EAW76394 P08631 AK026432 BAB15482 AK225819 AK289896 BAF82585 AK290928 BAF83617 AK298726 BAG60878 AK314335 AW139272 BC014435 AAH14435 BC073748 AAH73748 BC094847 AAH94847 BC108930 AAI08931 BC108931 AAI08932 BC113854 AAI13855 BC114463 AAI14464 DA465978 M16592 AAA52644 NM_001172129 NP_001165600 NM_001172130 NP_001165601 NM_001172131 NP_001165602 NM_001172132 NP_001165603 NM_001172133 NP_001165604 NM_002110 NP_002101 |
| Function | Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation |
| Subcellular Location | Cytoplasmic vesicle, secretory vesicle. Cytoplasm, cytosol. |
| Tissue Specificity | Detected in monocytes and neutrophils (at protein level). Expressed predominantly in cells of the myeloid and B-lymphoid lineages. Highly expressed in granulocytes. Detected in tonsil. {ECO:0000269|PubMed:3453117, ECO:0000269|PubMed:8064233, ECO:0000269|PubMed:8995234}. |
| Top Pathways | Fc gamma R-mediated phagocytosis, Chemokine signaling pathway |