CALHM1

Gene Symbol	CALHM1
Entrez Gene	255022
Alt Symbol	FAM26C
Species	Human
Gene Type	protein-coding
Description	calcium homeostasis modulator 1
Other Description	calcium homeostasis modulator protein 1|family with sequence similarity 26, member C
Swissprots	Q5W091 Q8IU99
Accessions	EAW49632 Q8IU99 BC036193 AAH36193 BC036208 AAH36208 JF432767 ADZ15984 NM_001001412 NP_001001412
Function	Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. {ECO:0000269|Pub
Subcellular Location	Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with HSPA5 at the endoplasmic reticulum.
Tissue Specificity	Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells. {ECO:0000269|PubMed:18585350, ECO:0000269|PubMed:19997627}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CALHM1 (G-15) - sc-164315 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CALHM1 antibody - ab106561 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CALHM1 antibody - ab116101 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CALHM1 antibody - ab87727 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CALHM1 Antibody (aa295-344) - LS-C145210 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-CALHM1 Antibody - LS-C140642 from LifeSpan Bioscience Prices $330.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CALHM1 Antibody (N-Terminus) - LS-C108656 from LifeSpan Bioscience Prices $345.00, $1,035.00 Sizes 100 µg, 500 µg Host Rabbit Clonality Polyclonal

CALHM1 Antibody - NBP1-77112 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CALHM1 Antibody - NBP1-83930 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1 Antibody - 43890002 from Novus Biologicals Prices $299.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody - bs-11642R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11642R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11642R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11642R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11642R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody, Cy3 Conjugated - bs-11642R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody, Cy5 Conjugated - bs-11642R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody, Cy5.5 Conjugated - bs-11642R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody, Cy7 Conjugated - bs-11642R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody, FITC Conjugated - bs-11642R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody, Biotin Conjugated - bs-11642R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CALHM1/FAM26C Polyclonal Antibody, HRP Conjugated - bs-11642R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CALHM1 antibody produced in rabbit - HPA018317 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CALHM1 antibody produced in rabbit - SAB3500243 from Sigma-Aldrich Prices $348.50 Sizes 100 µg Host Rabbit Clonality Polyclonal

Calcium-Homeostasis-Modulator-1-Antibody - AG1327 from Abgent, a WuXi AppTec company Prices $475.00, $575.00 Sizes 50 µl, 200 µl Host Rabbit Clonality Polyclonal

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