CALHM1

Gene Symbol	CALHM1
Entrez Gene	255022
Alt Symbol	FAM26C
Species	Human
Gene Type	protein-coding
Description	calcium homeostasis modulator 1
Other Description	calcium homeostasis modulator protein 1|family with sequence similarity 26, member C
Swissprots	Q5W091 Q8IU99
Accessions	EAW49632 Q8IU99 BC036193 AAH36193 BC036208 AAH36208 JF432767 ADZ15984 NM_001001412 NP_001001412
Function	Pore-forming subunit of a voltage-gated ion channel required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to changes in extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of Ca(2+), Na(+) and K(+), as well as permeation of monovalent anions. Acts as an activator of the ERK1 and ERK2 cascade. Triggers endoplasmic reticulum stress by reducing the calcium content of the endoplasmic reticulum. May indirectly control amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. {ECO:0000269|Pub
Subcellular Location	Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Colocalizes with HSPA5 at the endoplasmic reticulum.
Tissue Specificity	Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells. {ECO:0000269|PubMed:18585350, ECO:0000269|PubMed:19997627}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CALHM1 Antibody Blocking Peptide - LS-E16306 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CALHM1 Antibody Blocking Peptide - LS-E30858 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CALHM1 Blocking Peptide - NBP1-77112PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Recombinant Human CALHM1 Protein - H00255022-G01-10ug from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Species Human

CALHM1 Peptide - GTX85207-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

CALHM1 / FAM26C Control Peptide - AP30176CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

CALHM1 Peptide - 5593P from ProSci Category Peptide Species Human

CALHM1 fusion protein - ag14938 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CALHM1 fusion protein - ag16056 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human CALHM1 - CALHM1-1130H from Creative Biomart Category Protein Source Mammalian Cells Species Human

CALHM1 Protein - abx163960 from Abbexa Category Protein Species Human

CALHM1 Protein - NBP1-83930PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

CALHM1FAM26C-Antibody-Center-Blocking-Peptide - BP7399c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CALHM1FAM26C-Antibody-N-term-Blocking-Peptide - BP7399a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CALHM1 Peptide, Human - M34GP02298H from Creative Peptides Category Peptide Source Synthetic. Species Human

Calcium homeostasis modulator protein 1 (CALHM1), Recombinant Protein - MBS7010729 from MyBioSource Category Protein Prices $1,155.00, $2,140.00, $3,350.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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