TRPM8

Gene Symbol TRPM8
Entrez Gene 79054
Alt Symbol LTRPC6, TRPP8
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily M, member 8
Other Description LTrpC-6|long transient receptor potential channel 6|short form of the TRPM8 cationic channel|transient receptor melastatin 8 variant 1|transient receptor melastatin 8 variant 2|transient receptor potential cation channel subfamily M member 8|transient receptor potential p8|transient receptor potential subfamily M member 8|trp-p8
Swissprots Q7Z2W7 A0AVG2 Q6QNH9 Q3YFM7 Q8TDX8 Q8TAC3 Q9BVK1
Accessions EAW71067 EAW71068 Q7Z2W7 AB061779 BAB86335 AK303811 BAG64764 AY090109 AAM10446 AY328400 AAP92167 AY532375 AAS45275 AY532376 AAS45276 BC001135 AAH01135 BC033137 BC126342 AAI26343 BC143819 DQ139309 AAZ73614 FJ895300 ACQ66098 KC692993 AHF58360 KC692994 AHF58361 KC692995 AHF58362 XM_011511810 XP_011510112 NM_024080 NP_076985
Function Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outwar
Subcellular Location Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells. {ECO:0000250}.
Tissue Specificity Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors. {ECO:0000269|PubMed:11325849, ECO:0000269|PubMed:12858355, ECO:0000269|PubMed:16174775, ECO:0000269|PubMed:22128173}.
Top Pathways Inflammatory mediator regulation of TRP channels

TRPM8 (G-16) - sc-169688 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRPM8 (N-15) - sc-169689 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRPM8 (D-25) - sc-130903 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
TRPM8 (D-25): sc-130903. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human prostate carcinoma tissue showing cytoplasmic and membrane localization.

Anti-TRPM8 antibody - ab104569 from Abcam

Prices $400.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry on Rat spinal cord (paraffin section) using ab104569 at 1/200 dilution incubated overnight at 4C, developed with DAB/Ni and counterstained with hematoxylin.

Anti-TRPM8 antibody - ab63082 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPM8 antibody - ab111001 from Abcam

Host Goat
Clonality Polyclonal

Anti-TRPM8 antibody - ab85617 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRPM8 antibody (ab85617) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : PC3 (Human prostate carcinoma cell line) Whole Cell Lysate Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-TRPM8 antibody - ab71245 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRPM8 antibody (ab71245) at 1/50 dilutionLane 1 : Non-transfected 293 cell lysatesLane 2 : TRPM8 transfected 293 cell lysatesLysates/proteins at 2 µg per lane.

Anti-TRPM8 antibody - ab3243 from Abcam

Prices $401.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-TRPM8 antibody (ab3243) at 1/750 dilution + TRPM8 transfected Cos7 cell lysate

Anti-TRPM8 antibody [EPR4196(2)] - ab109308 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4196(2)
All lanes : Anti-TRPM8 antibody [EPR4196(2)] (ab109308) at 1/1000 dilutionLane 1 : HT-1376 cell lysates Lane 2 : LnCaP cell lysates Lane 3 : A549 cell lysates Lysates/proteins at 10 µg per lane.

Anti-TRPM8 antibody - Carboxyterminal end - ab71244 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRPM8 antibody - Carboxyterminal end (ab71244) at 1/50 dilutionLane 1 : Non-transfected 293 cell lysatesLane 2 : TRPM8 transfected 293 cell lysatesLysates/proteins at 2 µg per lane.

Anti-TRPM8 Antibody - LS-C39937 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody (aa900-950) - LS-C95072 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody - LS-C95102 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody (Internal) - LS-C145073 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody (Biotin) - LS-C181918 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody (DY650) - LS-C181919 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody (DY488) - LS-C181920 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody (HRP) - LS-C181921 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody (DY550) - LS-C181922 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody (aa656-680) - LS-C184151 from LifeSpan Bioscience

Prices $740.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody (aa656-680, Biotin) - LS-C184152 from LifeSpan Bioscience

Prices $800.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody (Extracellular Domain, clone EPR4196(2)) IHC-plus™ - LS-B6668 from LifeSpan Bioscience

Host Rabbit
Clonality Monoclonal
Clone EPR4196(2)
Anti-TRPM8 antibody IHC of human placenta, trophoblast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6668 dilution 1:50.

Anti-TRPM8 Antibody (aa656-680, CF) - LS-C184153 from LifeSpan Bioscience

Prices $800.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRPM8 Antibody (aa656-680, Rhodamine) - LS-C184154 from LifeSpan Bioscience

Prices $800.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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