| Gene Symbol |
TRPM8
|
| Entrez Gene |
79054
|
| Alt Symbol |
LTRPC6, TRPP8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily M, member 8
|
| Other Description |
LTrpC-6|long transient receptor potential channel 6|short form of the TRPM8 cationic channel|transient receptor melastatin 8 variant 1|transient receptor melastatin 8 variant 2|transient receptor potential cation channel subfamily M member 8|transient receptor potential p8|transient receptor potential subfamily M member 8|trp-p8
|
| Swissprots |
Q7Z2W7 A0AVG2 Q6QNH9 Q3YFM7 Q8TDX8 Q8TAC3 Q9BVK1
|
| Accessions |
EAW71067 EAW71068 Q7Z2W7 AB061779 BAB86335 AK303811 BAG64764 AY090109 AAM10446 AY328400 AAP92167 AY532375 AAS45275 AY532376 AAS45276 BC001135 AAH01135 BC033137 BC126342 AAI26343 BC143819 DQ139309 AAZ73614 FJ895300 ACQ66098 KC692993 AHF58360 KC692994 AHF58361 KC692995 AHF58362 XM_011511810 XP_011510112 NM_024080 NP_076985
|
| Function |
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outwar
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors. {ECO:0000269|PubMed:11325849, ECO:0000269|PubMed:12858355, ECO:0000269|PubMed:16174775, ECO:0000269|PubMed:22128173}.
|
| Top Pathways |
Inflammatory mediator regulation of TRP channels
|
