TRPM8

Gene Symbol	TRPM8
Entrez Gene	79054
Alt Symbol	LTRPC6, TRPP8
Species	Human
Gene Type	protein-coding
Description	transient receptor potential cation channel, subfamily M, member 8
Other Description	LTrpC-6|long transient receptor potential channel 6|short form of the TRPM8 cationic channel|transient receptor melastatin 8 variant 1|transient receptor melastatin 8 variant 2|transient receptor potential cation channel subfamily M member 8|transient receptor potential p8|transient receptor potential subfamily M member 8|trp-p8
Swissprots	Q7Z2W7 A0AVG2 Q6QNH9 Q3YFM7 Q8TDX8 Q8TAC3 Q9BVK1
Accessions	EAW71067 EAW71068 Q7Z2W7 AB061779 BAB86335 AK303811 BAG64764 AY090109 AAM10446 AY328400 AAP92167 AY532375 AAS45275 AY532376 AAS45276 BC001135 AAH01135 BC033137 BC126342 AAI26343 BC143819 DQ139309 AAZ73614 FJ895300 ACQ66098 KC692993 AHF58360 KC692994 AHF58361 KC692995 AHF58362 XM_011511810 XP_011510112 NM_024080 NP_076985
Function	Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outwar
Subcellular Location	Cell membrane; Multi-pass membrane protein. Membrane raft. Endoplasmic reticulum membrane. Note=Localizes to membrane rafts but is also located in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts (By similarity). Located in the endoplasmic reticulum in prostate cancer cells. {ECO:0000250}.
Tissue Specificity	Expressed in prostate. Also expressed in prostate tumors and in non-prostatic primary tumors such as colon, lung, breast and skin tumors. {ECO:0000269|PubMed:11325849, ECO:0000269|PubMed:12858355, ECO:0000269|PubMed:16174775, ECO:0000269|PubMed:22128173}.
Top Pathways	Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRPM8 peptide - ab95862 from Abcam Category Peptide

TRPM8 peptide - ab187961 from Abcam Category Peptide

TRPM8 peptide - ab172200 from Abcam Category Peptide

TRPM8 peptide - ab135094 from Abcam Category Peptide

TRPM8 Antibody Blocking Peptide - LS-E1204 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPM8 Antibody Blocking Peptide - LS-E1139 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPM8 Antibody Blocking Peptide - LS-E12568 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPM8 Antibody Blocking Peptide - LS-E9561 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPM8 Antibody Blocking Peptide - LS-E9562 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPM8 Antibody Blocking Peptide - LS-E9563 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPM8 Antibody Blocking Peptide - LS-E29332 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRPM8 Antibody Blocking Peptide - LS-E29333 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRPM8 Antibody Blocking Peptide - LS-E29334 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TRPM8 Blocking Peptide - NBP1-97311PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

TRPM8 Peptide - P3231 from Novus Biologicals Category Peptide Species Human

TRPM8-Antibody-N-term-Blocking-peptide - BP11668a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRPM8-Antibody-Center-Blocking-peptide - BP11769c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRPM8-Antibody-C-term-C940-Blocking-Peptide - BP8181d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRPM8-Antibody-Center-R536-Blocking-Peptide - BP8181c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRPM8-Antibody-C-term-Blocking-Peptide - BP8181b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRPM8 blocking peptide - GTX88558-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

TRPM8 Blocking Peptide - 33R-10139 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRPM8 Blocking Peptide - abx063969 from Abbexa Category Peptide Species Human, Mouse, Rat

TRPM8 Peptide - AC21-1467-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRPM8 Peptide - 46-940P from ProSci Category Peptide

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