LEMD3

Gene Symbol LEMD3
Entrez Gene 23592
Alt Symbol MAN1
Species Human
Gene Type protein-coding
Description LEM domain containing 3
Other Description LEM domain-containing protein 3|inner nuclear membrane protein Man1|integral inner nuclear membrane protein
Swissprots Q9Y2U8 Q9NT47 Q9NYA5
Accessions AAF73293 EAW97148 EAW97149 Q9Y2U8 AF112299 AAD31593 AK024954 AK295406 BAG58357 AK304317 BAG65169 AK312473 AL137533 CAB70796 BC167864 AAI67864 BX390128 NM_001167614 NP_001161086 NM_014319 NP_055134
Function Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
Subcellular Location Nucleus inner membrane {ECO:0000269|PubMed:15647271}; Multi-pass membrane protein {ECO:0000269|PubMed:15647271}.
Tissue Specificity Heart, brain, placenta, lung, liver and skeletal muscle.

MAN1 (N-20) - sc-19785 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MAN1 (N-20): sc-19785. Western blot analysis of MAN1 expression in HL-60 nuclear extract.

MAN1 (H-50) - sc-50458 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MAN1 (H-50): sc-50458. Western blot analysis of MAN1 expression in PC-12 whole cell lysate.

MAN1 (E-20) - sc-19786 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-MAN1 antibody - ab124148 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of MAN1 in Human colon tissue with ab124148 at 5 ug/mL.

Anti-MAN1 antibody - ab121854 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab121854, at a 1/50 dilution, staining MAN1 in renal tubules of paraffin-embedded Human kidney tissue by Immunohistochemistry.

Anti-MAN1 antibody [3C8] - ab114031 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C8
All lanes : Anti-MAN1 antibody [3C8] (ab114031) at 1/500 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNA Lane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY MAN1 cDNA Lysates/proteins at 5 µg per lane.

Anti-MAN1 antibody [4E1] - ab123973 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E1
All lanes : Anti-MAN1 antibody [4E1] (ab123973) at 1/1000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY MAN1 cDNALysates/proteins at 5 µg per lane.

Anti-MAN1 antibody - N-terminal - ab157141 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MAN1 antibody - N-terminal (ab157141) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractLane 2 : HeLa total cell extract

Anti-LEMD3 / MAN1 Antibody (clone 6C10) - LS-C114869 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6C10
IHC of paraffin-embedded liver tissue using anti-LEMD3 mouse monoclonal antibody. (Dilution 1:50).

Anti-LEMD3 / MAN1 Antibody (clone 3C8) - LS-C337128 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C8
Western blot of extracts (35ug) from 9 different cell lines by using anti-LEMD3 monoclonal antibody.

Anti-LEMD3 / MAN1 Antibody (C-Terminus) IHC-plus™ - LS-B9587 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-LEMD3 / MAN1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9587 concentration 5 ug/ml.

Anti-LEMD3 / MAN1 Antibody (clone 3H1) - LS-C114871 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H1
Anti-LEMD3 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LEMD3.

LEMD3 Antibody (6C10) - NBP2-02211 from Novus Biologicals

Prices $379.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6C10

LEMD3 Antibody - NBP1-81265 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LEMD3 Antibody [NBP1-81265] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted)

Anti-LEMD3 (426-440) antibody produced in rabbit - L8169 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-LEMD3 (426-440): <B>Cat. No. L8169</B>: Immunofluorescence of HUVEC cells using LEMD3 (426-440), Cat. No. L8169 (red) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-LEMD3 (701-715) antibody produced in rabbit - L8294 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-LEMD3 (701-715): <B>Cat. No. L8294</B>: Immunofluorescence of HUVEC cells using LEMD3 (701-715), Cat. No. L8294 (red) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-LEMD3 antibody produced in rabbit - HPA025078 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LEMD3: <B>Cat. No. HPA025078</B>: Immunohistochemical staining of human kidney shows nuclear positivity often accentuated to the membrane in renal tubules.

Monoclonal Anti-LEMD3 antibody produced in mouse - SAB4100135 from Sigma-Aldrich

Prices $358.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone LEMD3-A55
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells expressing FLAG<SUP>®</SUP>-tagged human LEMD3 was separated on SDS-PAGE, probed with Mouse Anti-LEMD3 Clone: LEMD3-A55 (<B>Cat. No. SAB4100135</B>). The antibody was developed using Goat Anti-Mouse IgG-Peroxidase (<B>Cat. No. A2304</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000<BR/>2. Antibody dilution 1:2,000<BR/>3. Negative control<BR/>4. Positive control Anti-FLAG<SUP>®</SUP>

LEMD3 antibody [3H1] - GTX84221 from GeneTex

Prices $329.00
Sizes 100 μl
Host Mouse
Clonality Monoclonal
Clone 3H1
Anti-LEMD3 antibody [3H1] used in Flow cytometry/FACS. GTX84221

LEMD3 antibody [3H2] - GTX84222 from GeneTex

Prices $329.00
Sizes 100 μl
Host Mouse
Clonality Monoclonal
Clone 3H2
Anti-LEMD3 antibody [3H2] used in ICC/IF. GTX84222

LEMD3 antibody [4E1] - GTX84220 from GeneTex

Prices $369.00
Sizes 100 μl
Host Mouse
Clonality Monoclonal
Clone 4E1
Anti-LEMD3 antibody [4E1] used in ICC/IF. GTX84220

LEMD3 antibody [6C10] - GTX84223 from GeneTex

Prices $369.00
Sizes 100 μl
Host Mouse
Clonality Monoclonal
Clone 6C10
Anti-LEMD3 antibody [6C10] used in Flow cytometry/FACS. GTX84223

LEMD3 antibody - orb75695 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of human colon tissue lysate at 1 ug/mL using LEMD3 antibody

LEMD3 antibody - orb107113 from Biorbyt

Prices $476.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot (WB) of total cell extracts from a. mouse thymus, b. human HeLa; using anti-LEMD3 (N) (orb107113) at RT for 2 h.

LEMD3 antibody - 10R-4615 from Fitzgerald

Prices $455.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3H1
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