| Gene Symbol |
LEMD3
|
| Entrez Gene |
23592
|
| Alt Symbol |
MAN1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
LEM domain containing 3
|
| Other Description |
LEM domain-containing protein 3|inner nuclear membrane protein Man1|integral inner nuclear membrane protein
|
| Swissprots |
Q9Y2U8 Q9NT47 Q9NYA5
|
| Accessions |
AAF73293 EAW97148 EAW97149 Q9Y2U8 AF112299 AAD31593 AK024954 AK295406 BAG58357 AK304317 BAG65169 AK312473 AL137533 CAB70796 BC167864 AAI67864 BX390128 NM_001167614 NP_001161086 NM_014319 NP_055134
|
| Function |
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. {ECO:0000269|PubMed:15601644, ECO:0000269|PubMed:15647271}.
|
| Subcellular Location |
Nucleus inner membrane {ECO:0000269|PubMed:15647271}; Multi-pass membrane protein {ECO:0000269|PubMed:15647271}.
|
| Tissue Specificity |
Heart, brain, placenta, lung, liver and skeletal muscle.
|
![Western Blot: LEMD3 Overexpression Lysate (Adult Normal) [NBL1-12486] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LEMD3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9293_LEMD3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12486-img0002.jpg)