| Gene Symbol |
PLOD2
|
| Entrez Gene |
5352
|
| Alt Symbol |
BRKS2, LH2, TLH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
|
| Other Description |
lysine hydroxylase 2|lysyl hydroxlase 2|lysyl hydroxylase 2|procollagen-lysine,2-oxoglutarate 5-dioxygenase 2|telopeptide lysyl hydroxylase
|
| Swissprots |
O00469 B3KWS3 Q8N170 Q59ED2
|
| Accessions |
AAD40977 AAK20119 EAW78939 EAW78940 EAW78941 O00469 AB209879 BAD93116 AK125700 BAG54235 AK130098 AK295084 BAG58125 AL832238 BC016834 AAH16834 BC037169 AAH37169 BM724669 BX537521 U84573 AAB58363 XM_005247535 XP_005247592 XM_005247536 XP_005247593 NM_000935 NP_000926 NM_182943 NP_891988
|
| Function |
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
|
| Subcellular Location |
Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
|
| Tissue Specificity |
Highly expressed in pancreas and muscle. Isoform 1 and isoform 2 are expressed in the majority of the examined cell types. Isoform 2 is specifically expressed in skin, lung, dura and aorta. {ECO:0000269|PubMed:10372558}.
|
| Top Pathways |
Lysine degradation
|
![Western Blot: PLOD2 Overexpression Lysate (Adult Normal) [NBL1-14522] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PLOD2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/922_PLOD2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14522-img0002.jpg)