FBP1

Gene Symbol FBP1
Entrez Gene 2203
Alt Symbol FBP
Species Human
Gene Type protein-coding
Description fructose-1,6-bisphosphatase 1
Other Description D-fructose-1,6-bisphosphate 1-phosphohydrolase 1|FBPase 1|fructose-bisphosphatase 1|growth-inhibiting protein 17|liver FBPase
Swissprots P09467 Q53F94 Q96E46 O75571
Accessions AAC50207 AAW34363 BAF91908 CBF86692 CBG16870 CBV02277 CBV30316 EAW92617 P09467 AF073475 AAC25774 AK223395 BAD97115 AK292199 BAF84888 AK316583 BAG38171 AY544122 AAT11153 BC012927 AAH12927 D26054 BAA05051 D26055 BAA05052 D26056 BAA05053 DA962803 L10320 AAA35817 M19922 AAA35517 U47918 AAA89097 U47919 AAA89098 XM_006717005 XP_006717068 NM_000507 NP_000498 NM_001127628 NP_001121100
Function Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}.
Tissue Specificity Expressed in pancreatic islets. {ECO:0000269|PubMed:18375435}.
Top Pathways Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Insulin signaling pathway, AMPK signaling pathway, Glucagon signaling pathway

FBPase (A-4) - sc-166098 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FBPase (A-4): sc-166098. Western blot analysis of FBPase expression in non-transfected 293T: sc-117752 (A), human FBPase transfected 293T: sc-113796 (B) and HL-60 (C) whole cell lysates.

FBPase (C-10) - sc-166145 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FBPase (C-10): sc-166145. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing cytoplasmic staining of urothelial cells.

FBPase (F-9) - sc-166097 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FBPase (F-9): sc-166097. Western blot analysis of FBPase expression in non-transfected 293T: sc-117752 (A), human FBPase transfected 293T: sc-113796 (B) and HL-60 (C) whole cell lysates.

liver FBPase (B-11) - sc-376388 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
liver FBPase (B-11): sc-376388. Western blot analysis of FBPase expression in non-transfected: sc-117752 (A) and human FBPase transfected: sc-113796 (B) 293T whole cell lysates.

liver FBPase (B-10) - sc-166298 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
liver FBPase (B-10): sc-166298. Western blot analysis of FBPase expression in non-transfected: sc-117752 (A) and human FBPase transfected: sc-113796 (B) 293T whole cell lysates.

FBPase (H-300) - sc-66946 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FBPase (H-300): sc-66946. Western blot analysis of FBPase expression in non-transfected: sc-117752 (A) and human FBPase transfected: sc-113796 (B) 293T whole cell lysates.

liver FBPase (C-17) - sc-32432 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
liver FBPase (C-17): sc-32432. Western blot analysis of liver FBPase expression in HL-60 whole cell lysate.

liver FBPase (N-13) - sc-32430 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
liver FBPase (N-13): sc-32430. Western blot analysis of liver FBPase expression in non-transfected: sc-117752 (A) and human liver FBPase transfected: sc-113796 (B) 293T whole cell lysates.

Anti-FBP1 antibody - ab196556 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FBP1 antibody (ab196556) at 1/500 dilutionLane 1 : THP1 cell extractLane 2 : Mouse kidney extractLane 3 : Mouse liver extract

Anti-FBP1 antibody - ab191172 from Abcam

Prices $407.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling FBP1 with ab191172 at 1/75 dilution.

Anti-FBP1 antibody - ab103165 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab103165 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab103165, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-FBP1 antibody - ab67247 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-FBP1 antibody (ab67247) at 1/500 dilution + human stomach tissue lysate at 25 µg/mlSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-FBP1 antibody [EPR4619] - ab109020 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4619
All lanes : Anti-FBP1 antibody [EPR4619] (ab109020) at 1/10000 dilution (purified)Lane 1 : Mouse liverLane 2 : Rat liverLysates/proteins at 20 µg per lane.SecondaryHRP goat anti-rabbit (H+L) at 1/1000 dilution

Anti-FBP1 antibody [EPR4620] - ab109732 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4620
ICC/IF image of ab109732 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab109732, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-FBP1 Antibody - LS-C307487 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-FBP1 Antibody (Internal, clone EPR4620) - LS-C138083 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4620
Western blot analysis on (A) human stomach, (B) fetal liver, and (C) MCF-7 lysates using anti-FBP1 antibody.

Anti-FBP1 Antibody - LS-C310330 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FBP1 Antibody - LS-C341610 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FBP1 Antibody - LS-C334044 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of MCF-7 cell using FBP1 antibody. Blue: DAPI for nuclear staining.

Anti-FBP1 Antibody (Internal, clone EPR4619) - LS-C138379 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4619
IHC of paraffin-embedded human liver tissue using anti-FBP1 antibody.

Anti-FBP1 Antibody (aa1-31) IHC-plus™ - LS-B10706 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-FBP1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10706 dilution 1:75.

Anti-FBP1 Antibody (aa114-163) IHC-plus™ - LS-B8080 from LifeSpan Bioscience

Prices $450.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-FBP1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8080 dilution 2.5-5 ug/ml.

Anti-FBP1 Antibody (aa125-156) IHC-plus™ - LS-B10707 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-FBP1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10707 dilution 1:75.

FBPase 1 Antibody - NBP1-84721 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FBPase 1 Antibody [NBP1-84721] - Analysis in human liver tissue.

FBPase 1 Antibody - AF7285 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
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