| Gene Symbol |
FBP1
|
| Entrez Gene |
2203
|
| Alt Symbol |
FBP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fructose-1,6-bisphosphatase 1
|
| Other Description |
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1|FBPase 1|fructose-bisphosphatase 1|growth-inhibiting protein 17|liver FBPase
|
| Swissprots |
P09467 Q53F94 Q96E46 O75571
|
| Accessions |
AAC50207 AAW34363 BAF91908 CBF86692 CBG16870 CBV02277 CBV30316 EAW92617 P09467 AF073475 AAC25774 AK223395 BAD97115 AK292199 BAF84888 AK316583 BAG38171 AY544122 AAT11153 BC012927 AAH12927 D26054 BAA05051 D26055 BAA05052 D26056 BAA05053 DA962803 L10320 AAA35817 M19922 AAA35517 U47918 AAA89097 U47919 AAA89098 XM_006717005 XP_006717068 NM_000507 NP_000498 NM_001127628 NP_001121100
|
| Function |
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain. {ECO:0000269|PubMed:16497803, ECO:0000269|PubMed:18375435, ECO:0000269|PubMed:22517657}.
|
| Tissue Specificity |
Expressed in pancreatic islets. {ECO:0000269|PubMed:18375435}.
|
| Top Pathways |
Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Insulin signaling pathway, AMPK signaling pathway, Glucagon signaling pathway
|