Gene Symbol | CHST7 |
---|---|
Entrez Gene | 56548 |
Alt Symbol | C6ST-2, GST-5 |
Species | Human |
Gene Type | protein-coding |
Description | carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 |
Other Description | N-acetylglucosamine 6-O-sulfotransferase 4|carbohydrate sulfotransferase 7|chondroitin 6-sulfotransferase-2|galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5|glcNAc6ST-4|gn6st-4 |
Swissprots | O75667 Q9NS84 |
Accessions | CCQ43621 EAW59267 EAW59268 Q9NS84 AB037187 BAB03217 AB040711 BAB13770 BC023971 BC045537 AAH45537 BP250418 BQ940898 DA155923 DA277492 GQ129386 ACT64520 GQ129387 ACT64521 NM_019886 NP_063939 |
Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc. {ECO:0000269|PubMed:10781596, ECO:0000269|PubMed:10913333, ECO:0000269|PubMed:10956661}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in adult skin. {ECO:0000269|PubMed:10781596, ECO:0000269|PubMed:10913333, ECO:0000269|PubMed:10956661}. |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
CHST7 (L-18) - sc-68032 from Santa Cruz Biotechnology
|
||||||||
CHST7 (A-15) - sc-68030 from Santa Cruz Biotechnology
|
||||||||
CHST7 (E-20) - sc-68031 from Santa Cruz Biotechnology
|
||||||||
CHST7 (Z-24) - sc-133459 from Santa Cruz Biotechnology
|
||||||||
Anti-CHST7 Antibody (aa256-305) - LS-C31856 from LifeSpan Bioscience
|
||||||||
Carbohydrate Sulfotransferase 7/CHST7 Antibody - NBP2-15897 from Novus Biologicals
|
||||||||
Carbohydrate Sulfotransferase 7/CHST7 Antibody - NBP1-91248 from Novus Biologicals
|
||||||||
Anti-CHST7 antibody produced in rabbit - HPA003919 from Sigma-Aldrich
|
||||||||
Anti-CHST7 antibody produced in rabbit - SAB2701493 from Sigma-Aldrich
|
||||||||
Anti-CHST7 antibody produced in rabbit - AV41615 from Sigma-Aldrich
|
||||||||
CHST7 antibody - middle region (ARP41615_T100) - ARP41615_T100 from Aviva Systems Biology
|
||||||||
CHST7 antibody [N2C1], Internal - GTX120778 from GeneTex
|
||||||||
Mouse Carbohydrate Sulfotransferase 7/CHST7 Antibody - AF5108 from R&D Systems
|
||||||||
Mouse CHST7 Affinity Purified Polyclonal Ab, Goat IgG - AF5108-SP from R&D Systems
|
||||||||
CHST7 antibody - 70R-1906 from Fitzgerald
|
||||||||
Anti -CHST7 (Carbohydrate Sulfotransferase 7, Chondroitin 6-sulfotransferase 2, C6ST-2,GST-5, GlcNAc6ST-4, Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase5, N-acetylglucosamine 6-O-sulfotransferase 4, Gn6st-4) - 137844 from USBiological Life Science
|
||||||||
CHST7 antibody - H00056548-B01P from Acris Antibodies
|
||||||||
CHST7 Antibody - 29-606 from ProSci
|
||||||||
CHST7 antibody - 14359-1-AP from Proteintech Group
|
||||||||
CHST7 Antibody - GWB-14486C from Genway Biotech
|
||||||||
CHST7 - MBS276257 from MyBioSource
|
||||||||
CHST7, Polyclonal Antibody - MBS2521036 from MyBioSource
|
||||||||
CHST7 Antibody - EPP11558 from Elabscience
|
||||||||
Anti-CHST7 (aa 86-323) polyclonal antibody - DPABH-04674 from Creative Diagnostics
|
||||||||
Anti-CHST7 (aa 253-302) polyclonal antibody - DPABH-16518 from Creative Diagnostics
|