UBE2V1

Gene Symbol UBE2V1
Entrez Gene 7335
Alt Symbol CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A
Species Human
Gene Type protein-coding
Description ubiquitin-conjugating enzyme E2 variant 1
Other Description DNA-binding protein|TRAF6-regulated IKK activator 1 beta Uev1A
Swissprots E1P629 Q13404 Q9UM49 Q9H4J3 Q5TGE3 Q13532 Q13403 Q9GZW1 Q9UKL1 Q9H4J4 Q5TGE0 Q96H34 Q9GZT0 Q9UM50 Q9UM48
Accessions EAW75634 EAW75635 EAW75636 EAW75639 Q13404 AF049671 AI688615 AK314754 AL110132 AY008273 AAG24229 BC000468 AAH00468 BC005215 BC008944 AAH08944 BF446402 BF690501 BT007382 AAP36046 BU540046 BU595183 BU934624 BX375182 BX647511 BX648147 CA453411 CD103154 CF127653 CN346855 DA087027 DA409547 DA519011 DA573591 DA625165 DA642098 DA696213 DA885410 DA892136 DA916492 DB448941 HQ448675 ADQ33153 HY019085 U39360 AAB72015 U97279 AAC02780 U97280 AAC02755 U97281 AAC02756 NM_001032288 NP_001027459 NM_001257393 NP_001244322 NM_001257394 NP_001244323 NM_001257395 NP_001244324 NM_001257396 NP_001244325 NM_001257397 NP_001244326 NM_001257398 NP_001244327 NM_001257399 NP_001244328 NM_001282575 NP_001269504 NM_001282576 NP_001269505 NM_001282577 NP_001269506 NM_001282578 NP_001269507 NM_001282579 NP_001269508 NM_001282580 NP_001269509 NM_021988 NP_068823 NM_022442 NP_071887 NM_199144 NP_954595 NR_047554 NR_104218
Function Has no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. {ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:20061386, ECO:0000269|PubM
Subcellular Location Nucleus {ECO:0000269|PubMed:11076860, ECO:0000269|PubMed:9305758}. Note=Excluded from the nucleolus.
Tissue Specificity Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung. {ECO:0000269|PubMed:9418904, ECO:0000269|PubMed:9705497}.

Uev1A (L-14) - sc-15269 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Uev1A (L-14): sc-15269. Western blot analysis of Uev1A expression in mouse liver (A) and mouse brain (B) tissue extracts.

Uev1A (C-13) - sc-47556 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Uev1A (C-13): sc-47556. Western blot analysis of Uev1A expression in non-transfected: sc-117752 (A) and mouse Uev1A transfected: sc-127744 (B) 293T whole cell lysates.

Uev1A (H-6) - sc-390047 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Uev1A (H-6): sc-390047. Western blot analysis of Uev1A expression in non-transfected 293: sc-110760 (A), mouse Uev1A transfected 293: sc-110308 (B) and Jurkat (C) whole cell lysates and human liver tissue extract (D).

Uev1A/Mms2 (E-6) - sc-377254 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Uev1A/Mms2 (E-6): sc-377254. Western blot analysis of Mms2 expression in non-transfected: sc-117752 (A) and human Mms2 transfected: sc-117249 (B) 293T whole cell lysates and mouse liver (C) and human liver (D) tissue extracts.

Uev1A/Mms2 (C-12) - sc-377223 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Uev1A/Mms2 (C-12): sc-377223. Western blot analysis of Mms2 expression in non-transfected 293T: sc-117752 (A), human Mms2 transfected 293T: sc-117249 (B) and Jurkat (C) whole cell lysates and human liver (D) and mouse liver (E) tissue extracts.

Uev1A/Mms2 (F-11) - sc-377337 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Uev1A/Mms2 (F-11): sc-377337. Western blot analysis of Mms2 expression in non-transfected: sc-117752 (A) and human Mms2 transfected: sc-117249 (B) 293T whole cell lysates and human liver tissue extract (C).

Uev1A/Mms2 (G-6) - sc-514420 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Uev1A/Mms2 (G-6): sc-514420. Western blot analysis of Uev1A/Mms2 expression in Jurkat (A) and CCRF-CEM (B) whole cell lysates and human liver (C), human pancreas (D) and human spleen (E) tissue extracts.

Uev1A/Mms2 (K-16) - sc-47557 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Uev1A/Mms2 (K-16): sc-47557. Western blot analysis of Uev1A expression in non-transfected: sc-117752 (A) and mouse Uev1A transfected: sc-127744 (B) 293T whole cell lysates.

Anti-UEV1A antibody - ab25962 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-UEV1A antibody (ab25962) at 1 µg/mlLane 2 : Anti-UEV1A antibody (ab25962) at 2 µg/mlLane 3 : Anti-UEV1A antibody (ab25962) at 4 µg/mlLane 1 : Jurkat cell lysateLane 2 : Jurkat cell lysateLane 3 : Jurkat cell lysate

Anti-UEV1A antibody - ab167670 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Anti-UEV1A antibody (ab167670) at 1/500 dilution + Human pancreas lysate at 50 µg

Anti-UEV1A antibody - ab167656 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-UEV1A antibody (ab167656) at 1/500 dilutionLane 1 : UEV1A transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG HRP

Anti-UEV1A antibody - ab46949 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-UEV1A antibody (ab46949) at 1 µg/ml + Jurkat cell lysateObserved band size : 20 kDa (why is the actual band size different from the predicted?)Additional bands at : 97 kDa. We are unsure as to the identity of these extra bands.

Anti-UEV1B antibody - ab2714 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab2714 staining (3µg/ml) of K562 lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

Anti-UEV1 / UEV1A Antibody (C-Terminus) - LS-C451 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of UEV1A in Jurkat cell lysates with UEV1A antibody at (A) 1, (B) 2, and (C) 4 ug/ml.

Anti-UEV1 / UEV1A Antibody - LS-C26909 from LifeSpan Bioscience

Prices $360.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of UEV1A in Jurkat cell lysates with UEV1A antibody at (A) 1, (B) 2, and (C) 4 g/ml

Anti-UEV1 / UEV1A Antibody (C-Terminus, AP) - LS-C246306 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UEV1 / UEV1A Antibody (C-Terminus, APC) - LS-C246307 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UEV1 / UEV1A Antibody (C-Terminus, Biotin) - LS-C246308 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UEV1 / UEV1A Antibody (C-Terminus, FITC) - LS-C246309 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UEV1 / UEV1A Antibody (C-Terminus, PE) - LS-C246310 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UEV1 / UEV1A Antibody (C-Terminus, Azide-free, HRP) - LS-C247958 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UEV1 / UEV1A Antibody (C-Terminus) - LS-C330724 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UEV1 / UEV1A Antibody (N-Terminus) - LS-C20225 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Staining (3 ug/ml) of K562 lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by chemiluminescence.

Anti-UEV1 / UEV1A Antibody (C-Terminus) - LS-C145663 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
UBE2V1 antibody LS-C145663 Western blot of Fetal Brain lysate. Antibody concentration 1 ug/ml.

Anti-UEV1 / UEV1A Antibody (N-Terminus) - LS-C145417 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
UBE2V1 antibody LS-C145417 Western blot of Fetal Liver lysate. Antibody concentration 1 ug/ml.
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