UBE2V1

Gene Symbol	UBE2V1
Entrez Gene	7335
Alt Symbol	CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2 variant 1
Other Description	DNA-binding protein|TRAF6-regulated IKK activator 1 beta Uev1A
Swissprots	E1P629 Q13404 Q9UM49 Q9H4J3 Q5TGE3 Q13532 Q13403 Q9GZW1 Q9UKL1 Q9H4J4 Q5TGE0 Q96H34 Q9GZT0 Q9UM50 Q9UM48
Accessions	EAW75634 EAW75635 EAW75636 EAW75639 Q13404 AF049671 AI688615 AK314754 AL110132 AY008273 AAG24229 BC000468 AAH00468 BC005215 BC008944 AAH08944 BF446402 BF690501 BT007382 AAP36046 BU540046 BU595183 BU934624 BX375182 BX647511 BX648147 CA453411 CD103154 CF127653 CN346855 DA087027 DA409547 DA519011 DA573591 DA625165 DA642098 DA696213 DA885410 DA892136 DA916492 DB448941 HQ448675 ADQ33153 HY019085 U39360 AAB72015 U97279 AAC02780 U97280 AAC02755 U97281 AAC02756 NM_001032288 NP_001027459 NM_001257393 NP_001244322 NM_001257394 NP_001244323 NM_001257395 NP_001244324 NM_001257396 NP_001244325 NM_001257397 NP_001244326 NM_001257398 NP_001244327 NM_001257399 NP_001244328 NM_001282575 NP_001269504 NM_001282576 NP_001269505 NM_001282577 NP_001269506 NM_001282578 NP_001269507 NM_001282579 NP_001269508 NM_001282580 NP_001269509 NM_021988 NP_068823 NM_022442 NP_071887 NM_199144 NP_954595 NR_047554 NR_104218
Function	Has no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. {ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:20061386, ECO:0000269|PubM
Subcellular Location	Nucleus {ECO:0000269|PubMed:11076860, ECO:0000269|PubMed:9305758}. Note=Excluded from the nucleolus.
Tissue Specificity	Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung. {ECO:0000269|PubMed:9418904, ECO:0000269|PubMed:9705497}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human UBE2V1 full length protein - ab198472 from Abcam Category Protein Prices $359.00 Sizes 100 µg Source E. coli Species Human

Human UBE2V1 full length protein - ab133007 from Abcam Category Protein Source Wheat germ Species Human

Human UBE2V1 full length protein - ab173080 from Abcam Category Protein Source E. coli Species Human

Human UBE2V1 protein fragment - ab166401 from Abcam Category Protein Source Wheat germ Species Human

Human UEV1A peptide - ab39899 from Abcam Category Peptide Species Human

Human UEV1A peptide - ab22914 from Abcam Category Peptide Species Human

Human UEV1B peptide - ab22931 from Abcam Category Peptide Species Human

UBE2V1 protein (His tag) - Chemical Free - ab81565 from Abcam Category Protein Source E. coli Species Human

UEV1 / UEV1A Antibody Blocking Peptide - LS-E30086 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

UEV1 / UEV1A Blocking Peptide - LS-E25344 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UEV1 / UEV1A Antibody Blocking Peptide - LS-E22535 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UEV1 / UEV1A Antibody Blocking Peptide - LS-E22536 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UEV1 / UEV1A Antibody Blocking Peptide - LS-E6905 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Uev1a/UBE2V1 Protein - H00007335-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CBF1-interacting corepressor Protein - H00009541-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human CBF1-interacting corepressor Protein - H00009541-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Uev1a/UBE2V1 Blocking Peptide - NBP1-76442PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

Uev1a/UBE2V1 Peptide - P0966 from Novus Biologicals Category Peptide Species Human

Uev1a/UBE2V1 Peptide - P0964 from Novus Biologicals Category Peptide Species Human

Uev1a/UBE2V1 Peptide - P0963 from Novus Biologicals Category Peptide Species Human

UBE2V1-Antibody-C-term-Blocking-Peptide - BP2157b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UEV1A Peptide - GTX85082-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

Recombinant Human His6-Uev1a (Mms2)/UBE2V1, CF - E2-662-100 from R&D Systems Category Protein Source E. coli-derived, Contains a 6-His tag

Human Uev1a R protein - orb163549 from Biorbyt Category Protein Prices $213.00, $315.00, $536.00, $1,326.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli

UBE2V1 Blocking Peptide - 33R-10335 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

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