| Gene Symbol |
UBE2V1
|
| Entrez Gene |
7335
|
| Alt Symbol |
CIR1, CROC-1, CROC1, UBE2V, UEV-1, UEV1, UEV1A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2 variant 1
|
| Other Description |
DNA-binding protein|TRAF6-regulated IKK activator 1 beta Uev1A
|
| Swissprots |
E1P629 Q13404 Q9UM49 Q9H4J3 Q5TGE3 Q13532 Q13403 Q9GZW1 Q9UKL1 Q9H4J4 Q5TGE0 Q96H34 Q9GZT0 Q9UM50 Q9UM48
|
| Accessions |
EAW75634 EAW75635 EAW75636 EAW75639 Q13404 AF049671 AI688615 AK314754 AL110132 AY008273 AAG24229 BC000468 AAH00468 BC005215 BC008944 AAH08944 BF446402 BF690501 BT007382 AAP36046 BU540046 BU595183 BU934624 BX375182 BX647511 BX648147 CA453411 CD103154 CF127653 CN346855 DA087027 DA409547 DA519011 DA573591 DA625165 DA642098 DA696213 DA885410 DA892136 DA916492 DB448941 HQ448675 ADQ33153 HY019085 U39360 AAB72015 U97279 AAC02780 U97280 AAC02755 U97281 AAC02756 NM_001032288 NP_001027459 NM_001257393 NP_001244322 NM_001257394 NP_001244323 NM_001257395 NP_001244324 NM_001257396 NP_001244325 NM_001257397 NP_001244326 NM_001257398 NP_001244327 NM_001257399 NP_001244328 NM_001282575 NP_001269504 NM_001282576 NP_001269505 NM_001282577 NP_001269506 NM_001282578 NP_001269507 NM_001282579 NP_001269508 NM_001282580 NP_001269509 NM_021988 NP_068823 NM_022442 NP_071887 NM_199144 NP_954595 NR_047554 NR_104218
|
| Function |
Has no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. {ECO:0000269|PubMed:11057907, ECO:0000269|PubMed:20061386, ECO:0000269|PubM
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11076860, ECO:0000269|PubMed:9305758}. Note=Excluded from the nucleolus.
|
| Tissue Specificity |
Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung. {ECO:0000269|PubMed:9418904, ECO:0000269|PubMed:9705497}.
|