Gene Symbol | Leprot |
---|---|
Entrez Gene | 56766 |
Alt Symbol | Ob-Rgrp, Obrgrp |
Species | Rat |
Gene Type | protein-coding |
Description | leptin receptor overlapping transcript |
Other Description | OB-R gene-related protein|OB-receptor gene related protein (OB-RGRP)|endospanin-1|leptin receptor gene-related protein |
Swissprots | Q9JLS8 |
Accessions | CBX85067 EDL97833 Q9JLS8 AF139209 AAF63411 BC062003 AAH62003 FQ225517 NM_020099 NP_064484 |
Function | Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin (By similarity). Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000250, ECO:0000269|PubMed:19907080}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}. |