| Gene Symbol |
Leprot
|
| Entrez Gene |
56766
|
| Alt Symbol |
Ob-Rgrp, Obrgrp
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
leptin receptor overlapping transcript
|
| Other Description |
OB-R gene-related protein|OB-receptor gene related protein (OB-RGRP)|endospanin-1|leptin receptor gene-related protein
|
| Swissprots |
Q9JLS8
|
| Accessions |
CBX85067 EDL97833 Q9JLS8 AF139209 AAF63411 BC062003 AAH62003 FQ225517 NM_020099 NP_064484
|
| Function |
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin (By similarity). Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000250, ECO:0000269|PubMed:19907080}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
|