PARN

Gene Symbol	PARN
Entrez Gene	5073
Alt Symbol	DAN
Species	Human
Gene Type	protein-coding
Description	poly(A)-specific ribonuclease
Other Description	deadenylating nuclease|deadenylation nuclease|poly(A)-specific ribonuclease (deadenylation nuclease)|poly(A)-specific ribonuclease PARN|polyadenylate-specific ribonuclease
Swissprots	B4DWR4 O95453 B4E1H6 B4DDG8 B4DSB0 B2RCB3
Accessions	EAW85110 EAW85111 O95453 AJ005698 CAA06683 AK023866 BAG51231 AK293189 BAG56729 AK299653 BAG61572 AK301648 BAG63126 AK303348 BAG64410 AK315020 BAG37510 AW338742 BC044763 BC050029 AAH50029 BF435512 DA308295 JF432357 ADZ15574 XM_011522510 XP_011520812 XM_011522511 XP_011520813 XM_011522512 XP_011520814 XM_011522513 XP_011520815 XM_011522514 XP_011520816 XM_011546699 XP_011545001 XM_011546700 XP_011545002 XM_011546701 XP_011545003 XM_011546702 XP_011545004 XM_011546703 XP_011545005 NM_001134477 NP_001127949 NM_001242992 NP_001229921 NM_002582 NP_002573
Function	3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0
Subcellular Location	Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Some nuclear fraction is nucleolar.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:10640832, ECO:0000269|PubMed:9736620}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PARN-Over-expression-Lysate - LY13300a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

PARN 293T Cell Transient Overexpression Lysate(Denatured) - H00005073-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

PARN 293 Cell Lysate - 409011 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PARN Overexpression Lysate (Denatured) - H00005073-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

PARN Overexpression Lysate (Native) - NBL1-14109 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PARN Over-expression Lysate Product - GWB-EAA448 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human PARN Knockdown Stable Cell Line - CSC-DC011311 from Creative biogene Category Cell Line Species Human

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