PARN

Gene Symbol	PARN
Entrez Gene	5073
Alt Symbol	DAN
Species	Human
Gene Type	protein-coding
Description	poly(A)-specific ribonuclease
Other Description	deadenylating nuclease|deadenylation nuclease|poly(A)-specific ribonuclease (deadenylation nuclease)|poly(A)-specific ribonuclease PARN|polyadenylate-specific ribonuclease
Swissprots	B4DWR4 O95453 B4E1H6 B4DDG8 B4DSB0 B2RCB3
Accessions	EAW85110 EAW85111 O95453 AJ005698 CAA06683 AK023866 BAG51231 AK293189 BAG56729 AK299653 BAG61572 AK301648 BAG63126 AK303348 BAG64410 AK315020 BAG37510 AW338742 BC044763 BC050029 AAH50029 BF435512 DA308295 JF432357 ADZ15574 XM_011522510 XP_011520812 XM_011522511 XP_011520813 XM_011522512 XP_011520814 XM_011522513 XP_011520815 XM_011522514 XP_011520816 XM_011546699 XP_011545001 XM_011546700 XP_011545002 XM_011546701 XP_011545003 XM_011546702 XP_011545004 XM_011546703 XP_011545005 NM_001134477 NP_001127949 NM_001242992 NP_001229921 NM_002582 NP_002573
Function	3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization. {ECO:0000269|PubMed:10882133, ECO:0000269|PubMed:11359775, ECO:0
Subcellular Location	Nucleus. Cytoplasm. Nucleus, nucleolus. Note=Some nuclear fraction is nucleolar.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:10640832, ECO:0000269|PubMed:9736620}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PARN full length protein - ab114690 from Abcam Category Protein Source Wheat germ Species Human

Human PARN peptide - ab28513 from Abcam Category Peptide

Human PARN protein fragment - ab152588 from Abcam Category Protein Source Wheat germ Species Human

PARN Antibody Blocking Peptide - LS-E13404 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PARN Protein - H00005073-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PARN Protein - H00005073-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human PARN protein - orb245950 from Biorbyt Category Protein Prices $340.00, $629.00, $649.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human PARN protein - orb244428 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

PARN Blocking Peptide - 33R-3936 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PARN - H00005073-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PARN - H00005073-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PARN - H00005073-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PARN - H00005073-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PARN fusion protein - ag4783 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PARN fusion protein - ag4774 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PARN - PARN-30788TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Poly A Specific Ribonuclease (PARN) - RPC176Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Human Poly(A)-specific ribonuclease PARN(PARN) - CSB-YP017456HU CSB-BP017456HU CSB-MP017456HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human Poly(A)-specific ribonuclease PARN(PARN) - CSB-EP017456HU from Cusabio Category Protein Source Yeast Species Human

PARN (transcript variant 1) - TP307220 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Poly(A)-specific ribonuclease PARN, Recombinant Protein - MBS1121757 from MyBioSource Category Protein Prices $110.00, $190.00, $285.00, $460.00, $750.00, $1,180.00, $1,235.00, $1,485.00, $1,570.00, $2,235.00, $2,240.00, $2,940.00 Sizes 10 µg (Yeast), 50 µg (Yeast), 100 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Poly A Specific Ribonuclease, Recombinant Protein - MBS2029566 from MyBioSource Category Protein Prices $175.00, $370.00, $575.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

PARN Recombinant Protein Antigen - NBP1-84303PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PARN Recombinant Protein Antigen - NBP1-84302PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PARN Peptide, Human - M34GP11311H from Creative Peptides Category Peptide Source Synthetic. Species Human

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