| Gene Symbol |
INPP5E
|
| Entrez Gene |
56623
|
| Alt Symbol |
CORS1, CPD4, JBTS1, MORMS, PPI5PIV
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inositol polyphosphate-5-phosphatase, 72 kDa
|
| Other Description |
72 kDa inositol polyphosphate 5-phosphatase|phosphatidylinositol (4,5) bisphosphate 5-phosphatase|phosphatidylinositol 4,5-bisphosphate 5-phosphatase|phosphatidylinositol polyphosphate 5-phosphatase type IV|phosphatidylinositol-4,5-bisphosphate 5-phosphatase
|
| Swissprots |
Q6PIV5 Q9NRR6 Q15734
|
| Accessions |
EAW88233 EAW88234 EAW88235 Q9NRR6 AF187891 AAF81404 AL832846 BC028032 AAH28032 BC110356 AAI10357 BE044535 BE314630 U45974 AAB03215 XM_005266094 XP_005266151 XR_929828 NM_019892 NP_063945
|
| Function |
Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5- bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates. {ECO:0000269|PubMed:10764818}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19668215, ECO:0000269|PubMed:19668216, ECO:0000269|PubMed:24166846}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9JII1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JII1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JII1}. Cell membrane {ECO:0000250|UniProtKB:Q9WVR1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVR1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVR1}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9WVR1}. Cytoplasm {ECO:0000250|UniProtKB:Q9WVR1}. Note=Peripheral membrane protein associated with Golgi stacks. {ECO:0000250|UniProtKB:Q9JII1}.
|
| Tissue Specificity |
Detected in brain, heart, pancreas, testis and spleen. {ECO:0000269|PubMed:10764818}.
|
| Top Pathways |
Inositol phosphate metabolism, Phosphatidylinositol signaling system
|
