INPP5E

Gene Symbol INPP5E
Entrez Gene 56623
Alt Symbol CORS1, CPD4, JBTS1, MORMS, PPI5PIV
Species Human
Gene Type protein-coding
Description inositol polyphosphate-5-phosphatase, 72 kDa
Other Description 72 kDa inositol polyphosphate 5-phosphatase|phosphatidylinositol (4,5) bisphosphate 5-phosphatase|phosphatidylinositol 4,5-bisphosphate 5-phosphatase|phosphatidylinositol polyphosphate 5-phosphatase type IV|phosphatidylinositol-4,5-bisphosphate 5-phosphatase
Swissprots Q6PIV5 Q9NRR6 Q15734
Accessions EAW88233 EAW88234 EAW88235 Q9NRR6 AF187891 AAF81404 AL832846 BC028032 AAH28032 BC110356 AAI10357 BE044535 BE314630 U45974 AAB03215 XM_005266094 XP_005266151 XR_929828 NM_019892 NP_063945
Function Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5- bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates. {ECO:0000269|PubMed:10764818}.
Subcellular Location Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19668215, ECO:0000269|PubMed:19668216, ECO:0000269|PubMed:24166846}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9JII1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JII1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JII1}. Cell membrane {ECO:0000250|UniProtKB:Q9WVR1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVR1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVR1}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9WVR1}. Cytoplasm {ECO:0000250|UniProtKB:Q9WVR1}. Note=Peripheral membrane protein associated with Golgi stacks. {ECO:0000250|UniProtKB:Q9JII1}.
Tissue Specificity Detected in brain, heart, pancreas, testis and spleen. {ECO:0000269|PubMed:10764818}.
Top Pathways Inositol phosphate metabolism, Phosphatidylinositol signaling system

INPP5E CRISPR/Cas9 KO Plasmid (h) - sc-405923 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INPP5E HDR Plasmid (h) - sc-405923-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INPP5E Double Nickase Plasmid (h) - sc-405923-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INPP5E Double Nickase Plasmid (h2) - sc-405923-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INPP5E CRISPR Activation Plasmid (h) - sc-405923-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INPP5E CRISPR Activation Plasmid (h2) - sc-405923-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

INPP5E Lentiviral Activation Particles (h) - sc-405923-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INPP5E Lentiviral Activation Particles (h2) - sc-405923-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

INPP5E siRNA (h) - sc-92496 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

INPP5E shRNA Plasmid (h) - sc-92496-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

INPP5E shRNA (h) Lentiviral Particles - sc-92496-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

INPP5E RNAi - H00056623-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU045091 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0277 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0279 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0278 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN2448 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2448 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08026 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr08026

INPP5E siRNA (Human) - CRJ1153 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

INPP5E - MBS8238183 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human INPP5E (NM_019892.4) - SHH319733 from Creative biogene

Category siRNA
Species Reactivities Human

INPP5E shRNA Plasmid (Human) - CHJ1153 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

INPP5E miRNA 3'UTR clone - MiUTR3H-12733 from Creative biogene

Species Reactivities Human
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