| Gene Symbol |
KCNV1
|
| Entrez Gene |
27012
|
| Alt Symbol |
HNKA, KCNB3, KV2.3, KV8.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, voltage gated modifier subfamily V, member 1
|
| Other Description |
neuronal potassium channel alpha subunit HNKA|potassium channel Kv8.1|potassium channel, subfamily V, member 1|potassium voltage-gated channel subfamily V member 1|voltage-gated potassium channel subunit Kv8.1
|
| Swissprots |
Q9UHJ4 Q6PIU1
|
| Accessions |
BAA92316 BAC85099 EAW91938 Q6PIU1 AF035317 AF167082 AAD48031 AK297393 BAG59833 AK308123 AK313469 BAG36254 BC028739 AAH28739 DQ892413 ABM83339 DQ895627 ABM86553 XM_005250866 XP_005250923 NM_014379 NP_055194
|
| Function |
Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}; Multi-pass membrane protein {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}. Note=Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2.
|
| Tissue Specificity |
Detected in brain. {ECO:0000269|PubMed:12383276}.
|
![Western Blot: Kv8.1 Overexpression Lysate (Native) [NBP2-07348] - Kv8.1 Overexpression Lysate (Native) Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for KCNV1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1768_Kv8.1-Overexpression-Lysate-(Native)-Western-Blot-NBP2-07348-img0002.jpg)