Gene Symbol | KCNV1 |
---|---|
Entrez Gene | 27012 |
Alt Symbol | HNKA, KCNB3, KV2.3, KV8.1 |
Species | Human |
Gene Type | protein-coding |
Description | potassium channel, voltage gated modifier subfamily V, member 1 |
Other Description | neuronal potassium channel alpha subunit HNKA|potassium channel Kv8.1|potassium channel, subfamily V, member 1|potassium voltage-gated channel subfamily V member 1|voltage-gated potassium channel subunit Kv8.1 |
Swissprots | Q9UHJ4 Q6PIU1 |
Accessions | BAA92316 BAC85099 EAW91938 Q6PIU1 AF035317 AF167082 AAD48031 AK297393 BAG59833 AK308123 AK313469 BAG36254 BC028739 AAH28739 DQ892413 ABM83339 DQ895627 ABM86553 XM_005250866 XP_005250923 NM_014379 NP_055194 |
Function | Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}; Multi-pass membrane protein {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}. Note=Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2. |
Tissue Specificity | Detected in brain. {ECO:0000269|PubMed:12383276}. |
KCNV1 CRISPR/Cas9 KO Plasmid (h) - sc-411945 from Santa Cruz Biotechnology
|
||||||||
KCNV1 HDR Plasmid (h) - sc-411945-HDR from Santa Cruz Biotechnology
|
||||||||
KCNV1 Double Nickase Plasmid (h) - sc-411945-NIC from Santa Cruz Biotechnology
|
||||||||
KCNV1 Double Nickase Plasmid (h2) - sc-411945-NIC-2 from Santa Cruz Biotechnology
|
||||||||
KCNV1 CRISPR Activation Plasmid (h) - sc-411945-ACT from Santa Cruz Biotechnology
|
||||||||
KCNV1 CRISPR Activation Plasmid (h2) - sc-411945-ACT-2 from Santa Cruz Biotechnology
|
||||||||
KCNV1 Lentiviral Activation Particles (h) - sc-411945-LAC from Santa Cruz Biotechnology
|
||||||||
KCNV1 Lentiviral Activation Particles (h2) - sc-411945-LAC-2 from Santa Cruz Biotechnology
|
||||||||
KCNV1 siRNA (h) - sc-77448 from Santa Cruz Biotechnology
|
||||||||
KCNV1 shRNA Plasmid (h) - sc-77448-SH from Santa Cruz Biotechnology
|
||||||||
KCNV1 shRNA (h) Lentiviral Particles - sc-77448-V from Santa Cruz Biotechnology
|
||||||||
Kv8.1 RNAi - H00027012-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU058341 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN10997 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10997 from Sigma-Aldrich
|
||||||||
KCNV1 siRNA (Human) - CRH8921 from Cohesion Biosciences
|
||||||||
shRNA set against Human KCNV1 (NM_014379.2) - SHH323783 from Creative biogene
|
||||||||
shRNA set against Human KCNV1(NM_014379.2) - SHL192828 from Creative biogene
|
||||||||
KCNV1 shRNA Plasmid (Human) - CHH8921 from Cohesion Biosciences
|
||||||||
KCNV1 miRNA 3'UTR clone - MiUTR1H-05171 from Creative biogene
|