| Gene Symbol | PLK4 |
|---|---|
| Entrez Gene | 10733 |
| Alt Symbol | MCCRP2, SAK, STK18 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polo-like kinase 4 |
| Other Description | Snk akin kinase|serine/threonine-protein kinase 18|serine/threonine-protein kinase PLK4|serine/threonine-protein kinase Sak |
| Swissprots | Q96Q95 Q8IYF0 B7Z837 Q9UD84 O00444 Q9UDE2 B2RAL0 B7Z8G7 |
| Accessions | EAX05196 O00444 AB006972 BAB69958 AB741646 BAP74121 AI088969 AK302858 BAH13823 AK303399 BAH13953 AK314238 BAG36907 BC036023 AAH36023 BP328161 BU633758 DC402409 DQ894189 ABM85115 Y13115 CAA73575 Z25433 CAA80920 XM_005262701 XP_005262758 XM_011531552 XP_011529854 XM_011531553 XP_011529855 NM_001190799 NP_001177728 NM_001190801 NP_001177730 NM_014264 NP_055079 |
| Function | Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activat |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus {ECO:0000250}. Cleavage furrow. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows. |