PLK4

Gene Symbol	PLK4
Entrez Gene	10733
Alt Symbol	MCCRP2, SAK, STK18
Species	Human
Gene Type	protein-coding
Description	polo-like kinase 4
Other Description	Snk akin kinase|serine/threonine-protein kinase 18|serine/threonine-protein kinase PLK4|serine/threonine-protein kinase Sak
Swissprots	Q96Q95 Q8IYF0 B7Z837 Q9UD84 O00444 Q9UDE2 B2RAL0 B7Z8G7
Accessions	EAX05196 O00444 AB006972 BAB69958 AB741646 BAP74121 AI088969 AK302858 BAH13823 AK303399 BAH13953 AK314238 BAG36907 BC036023 AAH36023 BP328161 BU633758 DC402409 DQ894189 ABM85115 Y13115 CAA73575 Z25433 CAA80920 XM_005262701 XP_005262758 XM_011531552 XP_011529854 XM_011531553 XP_011529855 NM_001190799 NP_001177728 NM_001190801 NP_001177730 NM_014264 NP_055079
Function	Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activat
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus, nucleolus {ECO:0000250}. Cleavage furrow. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PLK4 protein fragment - ab125558 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active Staphylokinase full length protein - ab73828 from Abcam Category Protein Prices $239.00 Sizes 100 µg Source E. coli

Human PLK4 peptide - ab71393 from Abcam Category Peptide

Human PLK4 peptide - ab22924 from Abcam Category Peptide Species Human

Human PLK4 protein fragment - ab153121 from Abcam Category Protein Source Wheat germ Species Human

PLK4 / SAK Antibody Blocking Peptide - LS-E25311 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Staphylokinase Protein - NBP2-35312 from Novus Biologicals Category Protein Prices $69.00, $169.00, $669.00 Sizes 20 µg, 100 µg, 1 mg Source E. coli

Recombinant Human PLK4 Protein - H00010733-Q01 from Novus Biologicals Category Protein Prices $319.00, $369.00, $529.00 Sizes 2 µg, 10 µg, 25 µg Source Wheat Germ Species Human

PLK4 Recombinant Protein - P4771 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

PLK4 blocking peptide - GTX22642-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

PLK4 Immunizing peptide - orb17631 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

PLK4 Peptide - AC21-0139-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PLK4 / SAK / STK18 - H00010733-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PLK4 / SAK / STK18 - H00010733-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PLK4 / SAK / STK18 - P4771 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

Sak Peptide - 46-331P from ProSci Category Peptide Species Human

PLK4 fusion protein - Ag3605 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Staphylokinase - ENPS-295 from NeoScientific Category Protein Prices $65.00, $169.00 Sizes 20 µg, 100 µg Source Escherichia Coli.

Recombinant Human Polo-like Kinase 4, GST-His - PLK4-705H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human PLK4, GST-tagged - PLK4-1789H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Staphylokinase - P01S0005 from BlueGene Biotech Category Protein Source E.coli

Recombinant Human Serine/threonine-protein kinase PLK4(PLK4) ,partial - CSB-YP018196HU CSB-EP018196HU CSB-BP018196HU CSB-MP018196HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Sak/STK18/PLK4, Peptide - MBS426562 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog, Bovine

Recombinant Human PLK4 GST-His Tagged Active - CRS014 from Cell Science Prices $1,795.00 Sizes 50 µg Source Sf9 insect cells Species Human

PLK4 Protein - NBP1-87095PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

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