| Gene Symbol |
SLC27A5
|
| Entrez Gene |
10998
|
| Alt Symbol |
ACSB, ACSVL6, BACS, BAL, FACVL3, FATP-5, FATP5, VLACSR, VLCS-H2, VLCSH2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 27 (fatty acid transporter), member 5
|
| Other Description |
BA-CoA ligase|VLACS-related|bile acid-CoA ligase|bile acyl-CoA synthetase|cholate--CoA ligase|fatty acid transport protein 5|fatty-acid-Coenzyme A ligase, very long-chain 3|solute carrier family 27 member 5|very long-chain acyl-CoA synthetase homolog 2|very long-chain acyl-CoA synthetase-related protein
|
| Swissprots |
B4DPQ1 Q9Y2P5 B3KVP6
|
| Accessions |
EAW72601 Q9Y2P5 AB208931 BAD92168 AF064255 AAD29444 AK026640 AK123036 BAG53858 AK298446 BAG60663 BC146387 AAI46388 BC148807 AAI48808 BX103174 XM_011526363 XP_011524665 XM_011526364 XP_011524666 NM_012254 NP_036386
|
| Function |
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. {ECO:0000269|PubMed:10749848, ECO:0000269|PubMed:11980911}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:10479480}; Multi-pass membrane protein {ECO:0000269|PubMed:10479480}.
|
| Tissue Specificity |
Predominantly expressed in liver. {ECO:0000269|PubMed:10479480}.
|
| Top Pathways |
Primary bile acid biosynthesis, PPAR signaling pathway, Bile secretion
|