IPO4

Gene Symbol	IPO4
Entrez Gene	79711
Alt Symbol	Imp4
Species	Human
Gene Type	protein-coding
Description	importin 4
Other Description	imp4b|importin-4|importin-4b|ran-binding protein 4|ranBP4
Swissprots	B2RN95 Q8NCG8 Q2NL96 Q8TEX9 Q96SJ3 Q9H5L0 Q86TZ9 Q9BTI4
Accessions	EAW66078 EAW66079 EAW66080 EAW66081 EAW66082 EAW66083 EAW66084 EAW66085 EAW66086 EAW66087 EAW66088 Q8TEX9 AB208897 BAD92134 AF411122 AAL78660 AK026991 BAB15616 AK027871 BAB55421 AK056527 AK056702 BAG51791 AK057044 BAG51851 AK057277 BAG51895 AK074743 BAC11174 AK094107 BAG52816 AK094897 BAG52950 AK095306 BAG53025 AK302097 BAG63479 AK314305 BC003690 AAH03690 BC110804 AAI10805 BC136759 AAI36760 BC144399 BC144400 BF001674 BG333193 BX248267 CAD62595 CR457367 CAG33648 NM_024658 NP_078934 NR_051979
Function	Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000250, ECO:0000269|PubMed:11823430}.
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Importin4 peptide - ab28905 from Abcam Category Peptide

Human Importin4 peptide - ab28906 from Abcam Category Peptide

Human Signal peptide peptidase-like 2B peptide - ab43855 from Abcam Category Peptide

Importin4 protein (His-DHFR tag) - ab127382 from Abcam Category Protein Source E. coli Species Human

IMP4 Antibody Blocking Peptide - LS-E23735 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IMP4 Antibody Blocking Peptide - LS-E10085 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IPO4 Antibody Blocking Peptide - LS-E24461 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IMP4 Protein - H00092856-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IPO4 fusion protein - Ag2281 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human IPO4, GST-tagged - IPO4-144H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Importin-4(IPO4) ,partial - CSB-YP823474HU CSB-EP823474HU CSB-BP823474HU CSB-MP823474HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RanBP4 / Importin-4 - TP311049 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Importin4 Recombinant Protein Antigen - NBP1-89841PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

IMP4 Peptide, Human - M34GP07628H from Creative Peptides Category Peptide Source Synthetic. Species Human

IPO4 Peptide, Human - M34GP07703H from Creative Peptides Category Peptide Source Synthetic. Species Human

IMP4 Recombinant Protein Antigen - NBP2-56330PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Importin4 Recombinant Protein Antigen - NBP2-56986PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

IMP4 Recombinant Protein Antigen - NBP2-55739PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Importin-4 (IPO4), partial, Recombinant Protein - MBS1398840 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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