IPO4
| Gene Symbol | IPO4 |
|---|---|
| Entrez Gene | 79711 |
| Alt Symbol | Imp4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | importin 4 |
| Other Description | imp4b|importin-4|importin-4b|ran-binding protein 4|ranBP4 |
| Swissprots | B2RN95 Q8NCG8 Q2NL96 Q8TEX9 Q96SJ3 Q9H5L0 Q86TZ9 Q9BTI4 |
| Accessions | EAW66078 EAW66079 EAW66080 EAW66081 EAW66082 EAW66083 EAW66084 EAW66085 EAW66086 EAW66087 EAW66088 Q8TEX9 AB208897 BAD92134 AF411122 AAL78660 AK026991 BAB15616 AK027871 BAB55421 AK056527 AK056702 BAG51791 AK057044 BAG51851 AK057277 BAG51895 AK074743 BAC11174 AK094107 BAG52816 AK094897 BAG52950 AK095306 BAG53025 AK302097 BAG63479 AK314305 BC003690 AAH03690 BC110804 AAI10805 BC136759 AAI36760 BC144399 BC144400 BF001674 BG333193 BX248267 CAD62595 CR457367 CAG33648 NM_024658 NP_078934 NR_051979 |
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000250, ECO:0000269|PubMed:11823430}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Ran BP-4 CRISPR/Cas9 KO Plasmid (h) - sc-407837 from Santa Cruz Biotechnology
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Ran BP-4 HDR Plasmid (h) - sc-407837-HDR from Santa Cruz Biotechnology
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Ran BP-4 Double Nickase Plasmid (h) - sc-407837-NIC from Santa Cruz Biotechnology
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Ran BP-4 Double Nickase Plasmid (h2) - sc-407837-NIC-2 from Santa Cruz Biotechnology
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Ran BP-4 CRISPR Activation Plasmid (h) - sc-407837-ACT from Santa Cruz Biotechnology
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Ran BP-4 CRISPR Activation Plasmid (h2) - sc-407837-ACT-2 from Santa Cruz Biotechnology
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Ran BP-4 Lentiviral Activation Particles (h) - sc-407837-LAC from Santa Cruz Biotechnology
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Ran BP-4 Lentiviral Activation Particles (h2) - sc-407837-LAC-2 from Santa Cruz Biotechnology
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Ran BP-4 siRNA (h) - sc-62922 from Santa Cruz Biotechnology
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Ran BP-4 shRNA Plasmid (h) - sc-62922-SH from Santa Cruz Biotechnology
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Ran BP-4 shRNA (h) Lentiviral Particles - sc-62922-V from Santa Cruz Biotechnology
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Importin4 RNAi - H00079711-R01 from Novus Biologicals
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MISSION® esiRNA - EHU083291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10731 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01447 from Sigma-Aldrich
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IPO4 siRNA (Human) - CRJ2505 from Cohesion Biosciences
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IPO4 - MBS8210550 from MyBioSource
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shRNA set against Human IPO4 (NM_024658.3) - SHH320165 from Creative biogene
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shRNA set against Human IPO4(NM_024658.3) - SHL177030 from Creative biogene
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Human IPO4 siRNA - orb273006 from Biorbyt
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IPO4 shRNA Plasmid (Human) - CHJ2505 from Cohesion Biosciences
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IPO4 miRNA 3'UTR clone - MiUTR1H-04976 from Creative biogene
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