| Gene Symbol |
Bnip3
|
| Entrez Gene |
12176
|
| Alt Symbol |
Nip3
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
BCL2/adenovirus E1B interacting protein 3
|
| Other Description |
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3|BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3|BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3|BCL2/adenovirus E1B interacting protein 1, NIP3
|
| Swissprots |
O55003 Q544Y4
|
| Accessions |
EDL17839 EDL17840 O55003 AF041054 AAD02922 AK014223 BAB29214 AK075943 BAC36072 AK152610 BAE31356 AK170865 AV091103 BC033278 BC046603 AAH46603 NM_009760 NP_033890
|
| Function |
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an importa
|
| Subcellular Location |
Mitochondrion. Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane (By similarity). {ECO:0000250}.
|
| Top Pathways |
Legionellosis
|
