| Gene Symbol | Bnip3 |
|---|---|
| Entrez Gene | 12176 |
| Alt Symbol | Nip3 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | BCL2/adenovirus E1B interacting protein 3 |
| Other Description | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3|BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3|BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3|BCL2/adenovirus E1B interacting protein 1, NIP3 |
| Swissprots | O55003 Q544Y4 |
| Accessions | EDL17839 EDL17840 O55003 AF041054 AAD02922 AK014223 BAB29214 AK075943 BAC36072 AK152610 BAE31356 AK170865 AV091103 BC033278 BC046603 AAH46603 NM_009760 NP_033890 |
| Function | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an importa |
| Subcellular Location | Mitochondrion. Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane (By similarity). {ECO:0000250}. |
| Top Pathways | Legionellosis |
BNIP-3 CRISPR/Cas9 KO Plasmid (m) - sc-419356 from Santa Cruz Biotechnology
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BNIP-3 HDR Plasmid (m) - sc-419356-HDR from Santa Cruz Biotechnology
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BNIP-3 Double Nickase Plasmid (m) - sc-419356-NIC from Santa Cruz Biotechnology
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BNIP-3 Double Nickase Plasmid (m2) - sc-419356-NIC-2 from Santa Cruz Biotechnology
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BNIP-3 CRISPR Activation Plasmid (m) - sc-419356-ACT from Santa Cruz Biotechnology
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BNIP-3 CRISPR Activation Plasmid (m2) - sc-419356-ACT-2 from Santa Cruz Biotechnology
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BNIP-3 Lentiviral Activation Particles (m) - sc-419356-LAC from Santa Cruz Biotechnology
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BNIP-3 Lentiviral Activation Particles (m2) - sc-419356-LAC-2 from Santa Cruz Biotechnology
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BNIP-3 siRNA (m) - sc-37452 from Santa Cruz Biotechnology
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BNIP-3 shRNA Plasmid (m) - sc-37452-SH from Santa Cruz Biotechnology
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BNIP-3 shRNA (m) Lentiviral Particles - sc-37452-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU192101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN27673 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27673 from Sigma-Aldrich
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BNIP3 siRNA (Mouse) - CRM0406 from Cohesion Biosciences
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BNIP3 - MBS8205601 from MyBioSource
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shRNA set against Mouse BNIP3 (NM_009760.4) - SHH247278 from Creative biogene
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shRNA set against Mouse Bnip3(NM_009760.4) - SHG102961 from Creative biogene
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BNIP3 shRNA Plasmid (Mouse) - CHM0406 from Cohesion Biosciences
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BNIP3 miRNA 3'UTR clone - MiUTR1M-02240 from Creative biogene
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