Gene Symbol | Bnip3 |
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Entrez Gene | 12176 |
Alt Symbol | Nip3 |
Species | Mouse |
Gene Type | protein-coding |
Description | BCL2/adenovirus E1B interacting protein 3 |
Other Description | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3|BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3|BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3|BCL2/adenovirus E1B interacting protein 1, NIP3 |
Swissprots | O55003 Q544Y4 |
Accessions | EDL17839 EDL17840 O55003 AF041054 AAD02922 AK014223 BAB29214 AK075943 BAC36072 AK152610 BAE31356 AK170865 AV091103 BC033278 BC046603 AAH46603 NM_009760 NP_033890 |
Function | Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an importa |
Subcellular Location | Mitochondrion. Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane (By similarity). {ECO:0000250}. |
Top Pathways | Legionellosis |
NIP3-BH3-Domain-Peptide - SP1019a from Abgent, a WuXi AppTec company
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Recombinant Mouse BNIP3 Protein - BNIP3-2448M from Creative Biomart
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BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3), Recombinant Protein - MBS1046915 from MyBioSource
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BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3), Recombinant Protein - MBS7010439 from MyBioSource
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Recombinant Mouse BNIP3 Protein (1-156 aa), His-tagged - BNIP3-2403M from Creative Biomart
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