| Gene Symbol |
AMOT
|
| Entrez Gene |
154796
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
angiomotin
|
| Other Description |
angiomotin p130 isoform|angiomotin p80 isoform
|
| Swissprots |
Q4VCS5 Q9HD27 Q9UPT1 Q504X5
|
| Accessions |
EAX02626 EAX02627 Q4VCS5 AB028994 BAA83023 AF286598 AAG01851 AK024344 AK301573 BAG63066 AY987378 AAY24451 BC039408 BC050581 BC094712 AAH94712 BC130294 AAI30295 XM_005262087 XP_005262144 XM_005262088 XP_005262145 XM_005262090 XP_005262147 XM_011530875 XP_011529177 NM_001113490 NP_001106962 NM_133265 NP_573572
|
| Function |
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. {ECO:0000269|PubMed:11257124, ECO:0000269|PubMed:16678097}.
|
| Subcellular Location |
Cell junction, tight junction {ECO:0000269|PubMed:16043488}. Note=Localized on the cell surface. May act as a transmembrane protein.
|
| Tissue Specificity |
Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta. {ECO:0000269|PubMed:11257124}.
|
| Top Pathways |
Hippo signaling pathway
|
![Western Blot: AMOT Overexpression Lysate [H00154796-T01] - Lane 1: AMOT transfected lysate (74.36 KDa) Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/26891_AMOT%2520Overexpression%2520Lysate-Western%2520Blot-H00154796-T01-img0002.jpg)
![Western Blot: AMOT Overexpression Lysate (Adult Normal) [NBP2-05714] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for AMOT.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10138_AMOT%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05714-img0001.jpg)