Gene Symbol | PFAS |
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Entrez Gene | 5198 |
Alt Symbol | FGAMS, FGAR-AT, FGARAT, PURL |
Species | Human |
Gene Type | protein-coding |
Description | phosphoribosylformylglycinamidine synthase |
Other Description | FGAM synthase|FGAR amidotransferase|formylglycinamide ribonucleotide amidotransferase|formylglycinamide ribotide amidotransferase|formylglycinamide ribotide synthetase |
Swissprots | O15067 A6H8V8 |
Accessions | EAW90067 EAW90068 EAW90069 O15067 AB002359 BAA20816 AK292402 BAF85091 AK292804 BAF85493 AK295895 BAG58688 AL044326 AY545554 BC006522 AAH06522 BC009318 BC031807 BC063538 AAH63538 BC146768 AAI46769 BC167158 AAI67158 DQ576789 XM_006721546 XP_006721609 XM_011523937 XP_011522239 XM_011523938 XP_011522240 XR_934047 NM_012393 NP_036525 |
Function | Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Top Pathways | Purine metabolism |
FGAM Synthase CRISPR/Cas9 KO Plasmid (h) - sc-410932 from Santa Cruz Biotechnology
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FGAM Synthase HDR Plasmid (h) - sc-410932-HDR from Santa Cruz Biotechnology
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FGAM Synthase Double Nickase Plasmid (h) - sc-410932-NIC from Santa Cruz Biotechnology
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FGAM Synthase Double Nickase Plasmid (h2) - sc-410932-NIC-2 from Santa Cruz Biotechnology
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FGAM Synthase CRISPR Activation Plasmid (h) - sc-410932-ACT from Santa Cruz Biotechnology
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FGAM Synthase CRISPR Activation Plasmid (h2) - sc-410932-ACT-2 from Santa Cruz Biotechnology
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FGAM Synthase Lentiviral Activation Particles (h) - sc-410932-LAC from Santa Cruz Biotechnology
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FGAM Synthase Lentiviral Activation Particles (h2) - sc-410932-LAC-2 from Santa Cruz Biotechnology
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FGAM Synthase siRNA (h) - sc-93608 from Santa Cruz Biotechnology
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FGAM Synthase shRNA Plasmid (h) - sc-93608-SH from Santa Cruz Biotechnology
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FGAM Synthase shRNA (h) Lentiviral Particles - sc-93608-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU057591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16648 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16648 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08524 from Sigma-Aldrich
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PFAS siRNA (Human) - CRH3470 from Cohesion Biosciences
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shRNA set against Human PFAS (NM_012393.2) - SHH373844 from Creative biogene
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PFAS shRNA Plasmid (Human) - CHH3470 from Cohesion Biosciences
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PFAS miRNA 3'UTR clone - MiUTR3H-04697 from Creative biogene
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