| Gene Symbol |
NACA2
|
| Entrez Gene |
342538
|
| Alt Symbol |
ANAC, NACAL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nascent polypeptide-associated complex alpha subunit 2
|
| Other Description |
IgE autoantigen alpha-nascent polypeptide-associated complex|alpha-NAC protein|hom s 2.01 protein|nascent polypeptide-associated complex subunit alpha-2|nascent polypeptide-associated complex, alpha polypeptide, 2
|
| Swissprots |
Q2VIR9 Q9H009
|
| Accessions |
ABB92399 CAC06614 Q9H009 BC062710 AAH62710 HQ447566 ADQ32052 NM_199290 NP_954984
|
| Function |
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Expressed specifically in testis and skeletal muscle. {ECO:0000269|PubMed:16201836}.
|
![Western Blot: NACA2 Overexpression Lysate (Adult Normal) [NBL1-13455] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NACA2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/19220_NACA2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-13455-img0002.jpg)