Gene Symbol | NACA2 |
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Entrez Gene | 342538 |
Alt Symbol | ANAC, NACAL |
Species | Human |
Gene Type | protein-coding |
Description | nascent polypeptide-associated complex alpha subunit 2 |
Other Description | IgE autoantigen alpha-nascent polypeptide-associated complex|alpha-NAC protein|hom s 2.01 protein|nascent polypeptide-associated complex subunit alpha-2|nascent polypeptide-associated complex, alpha polypeptide, 2 |
Swissprots | Q2VIR9 Q9H009 |
Accessions | ABB92399 CAC06614 Q9H009 BC062710 AAH62710 HQ447566 ADQ32052 NM_199290 NP_954984 |
Function | Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. |
Tissue Specificity | Expressed specifically in testis and skeletal muscle. {ECO:0000269|PubMed:16201836}. |
NACA2 CRISPR/Cas9 KO Plasmid (h) - sc-416544 from Santa Cruz Biotechnology
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NACA2 HDR Plasmid (h) - sc-416544-HDR from Santa Cruz Biotechnology
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NACA2 Double Nickase Plasmid (h) - sc-416544-NIC from Santa Cruz Biotechnology
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NACA2 Double Nickase Plasmid (h2) - sc-416544-NIC-2 from Santa Cruz Biotechnology
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NACA2 CRISPR Activation Plasmid (h) - sc-416544-ACT from Santa Cruz Biotechnology
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NACA2 CRISPR Activation Plasmid (h2) - sc-416544-ACT-2 from Santa Cruz Biotechnology
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NACA2 Lentiviral Activation Particles (h) - sc-416544-LAC from Santa Cruz Biotechnology
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NACA2 Lentiviral Activation Particles (h2) - sc-416544-LAC-2 from Santa Cruz Biotechnology
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NACA2 siRNA (h) - sc-93630 from Santa Cruz Biotechnology
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NACA2 shRNA Plasmid (h) - sc-93630-SH from Santa Cruz Biotechnology
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NACA2 shRNA (h) Lentiviral Particles - sc-93630-V from Santa Cruz Biotechnology
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NACA2 RNAi - H00342538-R01 from Novus Biologicals
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MISSION® esiRNA - EHU149611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14921 from Sigma-Aldrich
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NACA2 siRNA (Human) - CRJ7400 from Cohesion Biosciences
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shRNA set against Human NACA2 (NM_199290.3) - SHH348924 from Creative biogene
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Human NACA2 siRNA - orb277901 from Biorbyt
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NACA2 shRNA Plasmid (Human) - CHJ7400 from Cohesion Biosciences
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NACA2 miRNA 3'UTR clone - MiUTR3H-10520 from Creative biogene
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