| Gene Symbol |
CMTR2
|
| Entrez Gene |
55783
|
| Alt Symbol |
AFT, FTSJD1, HMTr2, MTr2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cap methyltransferase 2
|
| Other Description |
FtsJ methyltransferase domain containing 1|adrift homolog|cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2|cap2 2'O-ribose methyltransferase 2|ftsJ methyltransferase domain-containing protein 1|protein adrift homolog
|
| Swissprots |
Q9NXF5 Q8NE77 Q9H8Z4 Q8IYT2 Q9NUS3 Q8NFR5 B2RCD5 D3DWS1
|
| Accessions |
EAW59246 EAW59247 Q8IYT2 AA968997 AF458590 AAM49718 AK000289 BAA91058 AK002033 BAA92047 AK023183 BAB14452 AK123343 AK226169 AK315056 BAG37532 BC034468 AAH34468 BC035005 AAH35005 BX648660 DB227997 DB240113 XM_005256046 XP_005256103 XM_005256047 XP_005256104 XM_011523228 XP_011521530 XM_011523229 XP_011521531 NM_001099642 NP_001093112 NM_018348 NP_060818
|
| Function |
S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs. {ECO:0000269|PubMed:21310715}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21310715}. Cytoplasm {ECO:0000269|PubMed:21310715}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|