Gene Symbol | CMTR2 |
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Entrez Gene | 55783 |
Alt Symbol | AFT, FTSJD1, HMTr2, MTr2 |
Species | Human |
Gene Type | protein-coding |
Description | cap methyltransferase 2 |
Other Description | FtsJ methyltransferase domain containing 1|adrift homolog|cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2|cap2 2'O-ribose methyltransferase 2|ftsJ methyltransferase domain-containing protein 1|protein adrift homolog |
Swissprots | Q9NXF5 Q8NE77 Q9H8Z4 Q8IYT2 Q9NUS3 Q8NFR5 B2RCD5 D3DWS1 |
Accessions | EAW59246 EAW59247 Q8IYT2 AA968997 AF458590 AAM49718 AK000289 BAA91058 AK002033 BAA92047 AK023183 BAB14452 AK123343 AK226169 AK315056 BAG37532 BC034468 AAH34468 BC035005 AAH35005 BX648660 DB227997 DB240113 XM_005256046 XP_005256103 XM_005256047 XP_005256104 XM_011523228 XP_011521530 XM_011523229 XP_011521531 NM_001099642 NP_001093112 NM_018348 NP_060818 |
Function | S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the second nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) (cap0) to produce m(7)GpppRmpNm (cap2). Recognizes a guanosine cap on RNA independently of its N(7) methylation status. Display cap2 methylation on both cap0 and cap1. Displays a preference for cap1 RNAs. {ECO:0000269|PubMed:21310715}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:21310715}. Cytoplasm {ECO:0000269|PubMed:21310715}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
FTSJD1 CRISPR/Cas9 KO Plasmid (h) - sc-412604 from Santa Cruz Biotechnology
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FTSJD1 HDR Plasmid (h) - sc-412604-HDR from Santa Cruz Biotechnology
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FTSJD1 Double Nickase Plasmid (h) - sc-412604-NIC from Santa Cruz Biotechnology
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FTSJD1 Double Nickase Plasmid (h2) - sc-412604-NIC-2 from Santa Cruz Biotechnology
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FTSJD1 CRISPR Activation Plasmid (h) - sc-412604-ACT from Santa Cruz Biotechnology
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FTSJD1 CRISPR Activation Plasmid (h2) - sc-412604-ACT-2 from Santa Cruz Biotechnology
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FTSJD1 Lentiviral Activation Particles (h) - sc-412604-LAC from Santa Cruz Biotechnology
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FTSJD1 Lentiviral Activation Particles (h2) - sc-412604-LAC-2 from Santa Cruz Biotechnology
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FTSJD1 siRNA (h) - sc-93055 from Santa Cruz Biotechnology
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FTSJD1 shRNA Plasmid (h) - sc-93055-SH from Santa Cruz Biotechnology
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FTSJD1 shRNA (h) Lentiviral Particles - sc-93055-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU017471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8986 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8986 from Sigma-Aldrich
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CMTR2 siRNA (Human) - CRJ0917 from Cohesion Biosciences
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CMTR2 - MBS8235611 from MyBioSource
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shRNA set against Human FTSJD1 (NM_018348.5) - SHH297597 from Creative biogene
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shRNA set against Human FLJ11171(NM_018348.5) - SHH061517 from Creative biogene
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Human CMTR2 siRNA - orb271418 from Biorbyt
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CMTR2 shRNA Plasmid (Human) - CHJ0917 from Cohesion Biosciences
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FTSJD1 miRNA 3'UTR clone - MiUTR1H-03681 from Creative biogene
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FTSJD1 miRNA 3'UTR clone - MiUTR3H-14937 from Creative biogene
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