Gene Symbol |
LIF
|
Entrez Gene |
3976
|
Alt Symbol |
CDF, DIA, HILDA, MLPLI
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
leukemia inhibitory factor
|
Other Description |
D factor|cholinergic differentiation factor|differentiation inhibitory activity|differentiation-inducing factor|differentiation-stimulating factor|hepatocyte-stimulating factor III|human interleukin in DA cells|melanoma-derived LPL inhibitor
|
Swissprots |
B5MC23 B2RCW7 Q52LZ2 P15018
|
Accessions |
AAA51699 AAA53188 AAA59517 AAC05174 EAW59863 P15018 AI796373 AK315310 BAG37714 BC069540 AAH69540 BC093733 AAH93733 BC093735 AAH93735 BC143305 CK819709 CN409458 X13967 CAA32147 XM_006724240 XP_006724303 XM_011530172 XP_011528474 NM_001257135 NP_001244064 NM_002309 NP_002300
|
Function |
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
|
Subcellular Location |
Secreted.
|
Top Pathways |
Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, TNF signaling pathway, Signaling pathways regulating pluripotency of stem cells
|